CMKLR1 Antibody (PACO21012)
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주문- SKU:
- PACO21012
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CMKLR1 Antibody (PACO21012) |
Antibody SKU: | PACO21012 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human CMKLR1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO21012(CMKLR1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO21012(CMKLR1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid, derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). |
Synonyms: | chemerin chemokine-like receptor 1 |
UniProt Protein Function: | CMKLR1: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: 12q24.1 Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane Molecular Function:G-protein coupled receptor activity; protein binding; chemokine receptor activity; receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of interleukin-12 production; inhibition of NF-kappaB transcription factor; regulation of calcium-mediated signaling; positive regulation of fat cell differentiation; immune response; chemotaxis; skeletal development |
UniProt Code: | Q99788 |
NCBI GenInfo Identifier: | 17380487 |
NCBI Gene ID: | 1240 |
NCBI Accession: | Q99788.2 |
UniProt Secondary Accession: | Q99788,O75748, Q3KP37, Q5U0H0, Q99789, A8K6Y5, |
UniProt Related Accession: | Q99788 |
Molecular Weight: | 42,035 Da |
NCBI Full Name: | Chemokine-like receptor 1 |
NCBI Synonym Full Names: | chemokine-like receptor 1 |
NCBI Official Symbol: | CMKLR1 |
NCBI Official Synonym Symbols: | DEZ; RVER1; ChemR23; CHEMERINR |
NCBI Protein Information: | chemokine-like receptor 1; chemerin receptor; resolvin E1 receptor; chemokine receptor-like 1; G-protein coupled receptor DEZ; G-protein coupled receptor ChemR23; orphan G-protein coupled receptor, Dez |
UniProt Protein Name: | Chemokine-like receptor 1 |
UniProt Synonym Protein Names: | G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ |
UniProt Gene Name: | CMKLR1 |
UniProt Entry Name: | CML1_HUMAN |