CLPS Antibody (PACO16045)
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주문- SKU:
- PACO16045
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CLPS Antibody (PACO16045) |
Antibody SKU: | PACO16045 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human CLPS |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO16045(CLPS Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16045(CLPS Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | colipase, pancreatic |
UniProt Protein Function: | CLPS: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Belongs to the colipase family. |
UniProt Protein Details: | Protein type:Activator; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 6p21.31 Cellular Component: extracellular region Molecular Function:enzyme activator activity Biological Process: positive regulation of catalytic activity; phototransduction, visible light; lipid metabolic process; retinoid metabolic process; lipid catabolic process; lipid digestion |
NCBI Summary: | The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
UniProt Code: | P04118 |
NCBI GenInfo Identifier: | 116900 |
NCBI Gene ID: | 1208 |
NCBI Accession: | P04118.2 |
UniProt Secondary Accession: | P04118,Q5T9G7, Q5U809, |
UniProt Related Accession: | P04118 |
Molecular Weight: | 112 |
NCBI Full Name: | Colipase |
NCBI Synonym Full Names: | colipase, pancreatic |
NCBI Official Symbol: | CLPS |
NCBI Protein Information: | colipase; pancreatic colipase preproprotein |
UniProt Protein Name: | Colipase |
Protein Family: | Colipase |
UniProt Gene Name: | CLPS |
UniProt Entry Name: | COL_HUMAN |
Antibodies |
Anti-CLPS Antibody (CAB12772) |
Anti-CLPS Antibody (CAB13480) |
Anti-CLPS Antibody (CAB6364) |
CLPS Antibody (PACO08470) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |