CLEC4C Antibody (PACO18781)
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주문- SKU:
- PACO18781
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CLEC4C Antibody (PACO18781) |
Antibody SKU: | PACO18781 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human CLEC4C |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO18781(CLEC4C Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18781(CLEC4C Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. |
Synonyms: | C-type lectin domain family 4, member C |
UniProt Protein Function: | NRTN: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Belongs to the TGF-beta family. GDNF subfamily. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: axon; extracellular region Molecular Function:growth factor activity; receptor binding Biological Process: nervous system development; axon guidance; MAPKKK cascade; nerve development; neural crest cell migration; neurite development; transmembrane receptor protein tyrosine kinase signaling pathway Disease: Hirschsprung Disease, Susceptibility To, 1 |
NCBI Summary: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8WTT0 |
NCBI GenInfo Identifier: | 18466806 |
NCBI Gene ID: | 170482 |
NCBI Accession: | NP_569708 |
UniProt Related Accession: | Q8WTT0 |
Molecular Weight: | |
NCBI Full Name: | C-type lectin domain family 4 member C isoform 1 |
NCBI Synonym Full Names: | C-type lectin domain family 4 member C |
NCBI Official Symbol: | CLEC4C |
NCBI Official Synonym Symbols: | DLEC; HECL; BDCA2; CD303; BDCA-2; CLECSF7; CLECSF11; PRO34150 |
NCBI Protein Information: | C-type lectin domain family 4 member C |
UniProt Protein Name: | Neurturin |
Protein Family: | Neurturin |
UniProt Gene Name: | NRTN |
UniProt Entry Name: | NRTN_HUMAN |
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