CLDN5 Antibody (PACO23642)
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주문- SKU:
- PACO23642
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CLDN5 Antibody (PACO23642) |
Antibody SKU: | PACO23642 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from human CLDN5. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemical analysis of paraffin-embedded human brain tissue using Claudin 5 antibody. | |
Western blot analysis of extracts from 293 cells (Lane 2), K562 cells (Lane 3) and 3T3 cells (Lane 4), using Claudin 5 antiobdy. The lane on the left is treated with synthesized peptide. | |
Western blot analysis of extracts from A549 cells, using Claudin 5 antibody. |
Background: | Plays a major role in tight junction-specific obliteration of the intercellular space By similarity. |
Synonyms: | CLD5; CLDN5; TMDVCF; Transmembrane protein deleted in VCFS; |
UniProt Protein Function: | Claudin-5: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. |
UniProt Protein Details: | Protein type:Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 22q11.21 Cellular Component: apicolateral plasma membrane; cortical actin cytoskeleton; integral to membrane; intercellular junction; plasma membrane; tight junction Molecular Function:identical protein binding Biological Process: calcium-independent cell-cell adhesion; intercellular junction assembly; learning; palate development; transforming growth factor beta receptor signaling pathway |
NCBI Summary: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008] |
UniProt Code: | O00501 |
NCBI GenInfo Identifier: | 6685271 |
NCBI Gene ID: | 7122 |
NCBI Accession: | O00501.1 |
UniProt Secondary Accession: | O00501,Q53XW2, Q8WUW3, B3KS11, |
UniProt Related Accession: | O00501 |
Molecular Weight: | 23kDa |
NCBI Full Name: | Claudin-5 |
NCBI Synonym Full Names: | claudin 5 |
NCBI Official Symbol: | CLDN5 |
NCBI Official Synonym Symbols: | AWAL; BEC1; TMVCF; CPETRL1 |
NCBI Protein Information: | claudin-5 |
UniProt Protein Name: | Claudin-5 |
UniProt Synonym Protein Names: | Transmembrane protein deleted in VCFS; TMDVCF |
Protein Family: | Claudin |
UniProt Gene Name: | CLDN5 |
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