CLDN1 (Ab-210) Antibody (PACO23078)
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주문- SKU:
- PACO23078
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CLDN1 (Ab-210) Antibody (PACO23078) |
Antibody SKU: | PACO23078 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized non-phosphopeptide derived from human Claudin 1 around the phosphorylation site of tyrosine 210 (G-K-D-Y(p)-V). |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from HeLa cells, treated with Hu (2nM, 24hours), using Claudin 1 (Ab-210) antibody. | |
Western blot analysis of extracts from JK cells (Lane 2), using Claudin 1 (Ab-210) antiobdy. The lane on the left is treated with synthesized peptide. |
Background: | Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (). CLDN1 acts as a coreceptor for HCV entry into hepatic cells. |
Synonyms: | CLD1; CLDN1; SEMP1; Senescence-associated epithelial membrane protein; UNQ481/PRO944 |
UniProt Protein Function: | Claudin-1: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Acts as a co- receptor for HCV entry into hepatic cells. Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL. May interact with HCV E1 and E2 proteins. Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. Belongs to the claudin family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cytoskeletal; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3q28-q29 Cellular Component: integral to membrane; integral to plasma membrane; tight junction Molecular Function:identical protein binding; protein binding Biological Process: calcium-independent cell-cell adhesion; intercellular junction assembly and maintenance; protein heterooligomerization; protein homooligomerization Disease: Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis |
NCBI Summary: | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95832 |
NCBI GenInfo Identifier: | 6685283 |
NCBI Gene ID: | 9076 |
NCBI Accession: | O95832.1 |
UniProt Related Accession: | O95832 |
Molecular Weight: | 22,744 Da |
NCBI Full Name: | Claudin-1 |
NCBI Synonym Full Names: | claudin 1 |
NCBI Official Symbol: | CLDN1 |
NCBI Official Synonym Symbols: | CLD1; SEMP1; ILVASC |
NCBI Protein Information: | claudin-1 |
UniProt Protein Name: | Claudin-1 |
UniProt Synonym Protein Names: | Senescence-associated epithelial membrane protein |
Protein Family: | Claudin |
UniProt Gene Name: | CLDN1 |
UniProt Entry Name: | CLD1_HUMAN |
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