CLCN2 Antibody (PACO25777)
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주문- SKU:
- PACO25777
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CLCN2 Antibody (PACO25777) |
Antibody SKU: | PACO25777 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Chloride channel protein 2 protein (549-770AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescent analysis of HepG2 cells using PACO25777 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. |
Synonyms: | Chloride channel protein 2 (ClC-2), CLCN2 |
UniProt Protein Function: | CLCN2: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. Defects in CLCN2 are associated with susceptibility to epilepsy, idiopathic generalized type 11 (EIG11). A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CLCN2 are associated with juvenile absence epilepsy type 2 (JAE2). JAE is a subtype of idiopathic generalized epilepsy (IGE) characterized by onset occurring around puberty, absence seizures, generalized tonic- clonic seizures (GTCS), GTCS on awakening and myoclonic seizures. Defects in CLCN2 are associated with juvenile myoclonic epilepsy type 8 (EJM8). A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter; Transporter, ion channel; Channel, chloride; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3q27.1 Cellular Component: plasma membrane Molecular Function:voltage-gated chloride channel activity Biological Process: transport Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 11; Leukoencephalopathy With Ataxia |
NCBI Summary: | This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] |
UniProt Code: | P51788 |
NCBI GenInfo Identifier: | 288558807 |
NCBI Gene ID: | 1181 |
NCBI Accession: | P51788.2 |
UniProt Secondary Accession: | P51788,O14864, Q6IPA9, Q8WU13, B4DQT9, B4DZ58, E9PBD9 E9PCD2, |
UniProt Related Accession: | P51788 |
Molecular Weight: | 95,399 Da |
NCBI Full Name: | Chloride channel protein 2 |
NCBI Synonym Full Names: | chloride voltage-gated channel 2 |
NCBI Official Symbol: | CLCN2 |
NCBI Official Synonym Symbols: | CLC2; ECA2; ECA3; EGI3; EGMA; EJM6; EJM8; CIC-2; EGI11; LKPAT; clC-2 |
NCBI Protein Information: | chloride channel protein 2 |
UniProt Protein Name: | Chloride channel protein 2 |
Protein Family: | Chloride channel protein |
UniProt Gene Name: | CLCN2 |
UniProt Entry Name: | CLCN2_HUMAN |
Antibodies |
Anti-CLCN2 Antibody (CAB6120) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |