CKMT1A Antibody (PACO32764)
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주문- SKU:
- PACO32764
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CKMT1A Antibody (PACO32764) |
Antibody SKU: | PACO32764 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Creatine kinase U-type, mitochondrial protein (40-417AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO32764 at dilution of 1:100. | |
Immunofluorescent analysis of MCF-7 cells using PACO32764 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human prostate tissue using PACO32764 at dilution of 1:100. |
Background: | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
Synonyms: | Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (acid, c-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK), CKMT1A; CKMT1B, CKMT; CKMT |
UniProt Protein Function: | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
NCBI Summary: | Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008] |
UniProt Code: | P12532 |
NCBI GenInfo Identifier: | 125315 |
NCBI Gene ID: | 548596 |
NCBI Accession: | P12532.1 |
UniProt Secondary Accession: | P12532,Q0VAM3, Q32NF6, Q53FC4, B4DIT8, B7ZA09, |
UniProt Related Accession: | P12532 |
Molecular Weight: | 50,421 Da |
NCBI Full Name: | Creatine kinase U-type, mitochondrial |
NCBI Synonym Full Names: | creatine kinase, mitochondrial 1A |
NCBI Official Symbol: | CKMT1A |
NCBI Official Synonym Symbols: | CKMT1; U-MtCK; mia-CK |
NCBI Protein Information: | creatine kinase U-type, mitochondrial |
UniProt Protein Name: | Creatine kinase U-type, mitochondrial |
UniProt Synonym Protein Names: | Acidic-type mitochondrial creatine kinase; Mia-CK; Ubiquitous mitochondrial creatine kinase; U-MtCK |
UniProt Gene Name: | CKMT1A |
UniProt Entry Name: | KCRU_HUMAN |