CHRNA10 Antibody (PACO18264)
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주문- SKU:
- PACO18264
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CHRNA10 Antibody (PACO18264) |
Antibody SKU: | PACO18264 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human CHRNA10 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18264(CHRNA10 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18264(CHRNA10 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. |
Synonyms: | cholinergic receptor, nicotinic, α 10 (neuronal) |
UniProt Protein Function: | nAChRA10: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 10/CHRNA10 sub-subfamily. |
UniProt Protein Details: | Protein type:Channel, cation; Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: membrane; nicotinic acetylcholine-gated receptor-channel complex Molecular Function:acetylcholine binding; acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; receptor binding Biological Process: elevation of cytosolic calcium ion concentration; regulation of cell proliferation; synaptic transmission, cholinergic |
UniProt Code: | Q9GZZ6 |
NCBI GenInfo Identifier: | 14916526 |
NCBI Gene ID: | 57053 |
NCBI Accession: | Q9GZZ6.1 |
UniProt Related Accession: | Q9GZZ6 |
Molecular Weight: | 49,705 Da |
NCBI Full Name: | Neuronal acetylcholine receptor subunit alpha-10 |
NCBI Synonym Full Names: | cholinergic receptor nicotinic alpha 10 subunit |
NCBI Official Symbol: | CHRNA10 |
NCBI Protein Information: | neuronal acetylcholine receptor subunit alpha-10 |
UniProt Protein Name: | Neuronal acetylcholine receptor subunit alpha-10 |
UniProt Synonym Protein Names: | Nicotinic acetylcholine receptor subunit alpha-10; NACHR alpha-10 |
Protein Family: | Neuronal acetylcholine receptor |
UniProt Gene Name: | CHRNA10 |
UniProt Entry Name: | ACH10_HUMAN |