CHN1 Antibody (PACO44866)
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주문- SKU:
- PACO44866
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CHN1 Antibody (PACO44866) |
Antibody SKU: | PACO44866 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human N-chimaerin protein (1-200AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: CHN1 antibody at 6.08µg/ml. Lane 1: 293T whole cell lysate. Lane 2: MCF-7 whole cell lysate. Lane 3: Jurkat whole cell lysate. Lane 4: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 54, 39, 51 kDa. Observed band size: 51 kDa.. | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO44866 at dilution of 1:100. |
Background: | GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. |
Synonyms: | N-chimaerin (A-chimaerin) (Alpha-chimerin) (N-chimerin) (NC) (Rho GTPase-activating protein 2), CHN1, ARHGAP2 CHN |
UniProt Protein Function: | ARHGAP2: GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation. In neurons in brain regions that are involved in learning and memory processes. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GAPs; Adaptor/scaffold; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: cytosol Molecular Function:SH3/SH2 adaptor activity; ephrin receptor binding; metal ion binding; GTPase activator activity Biological Process: regulation of small GTPase mediated signal transduction; positive regulation of signal transduction; small GTPase mediated signal transduction; ephrin receptor signaling pathway; motor axon guidance; regulation of axonogenesis; positive regulation of GTPase activity Disease: Duane Retraction Syndrome 2 |
NCBI Summary: | This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] |
UniProt Code: | P15882 |
NCBI GenInfo Identifier: | 21903393 |
NCBI Gene ID: | 1123 |
NCBI Accession: | P15882.3 |
UniProt Related Accession: | P15882 |
Molecular Weight: | |
NCBI Full Name: | N-chimaerin |
NCBI Synonym Full Names: | chimerin 1 |
NCBI Official Symbol: | CHN1 |
NCBI Official Synonym Symbols: | NC; CHN; DURS2; ARHGAP2; RHOGAP2 |
NCBI Protein Information: | N-chimaerin |
UniProt Protein Name: | N-chimaerin |
UniProt Synonym Protein Names: | A-chimaerin; Alpha-chimerin; N-chimerin; NC; Rho GTPase-activating protein 2 |
Protein Family: | N-chimaerin |
UniProt Gene Name: | CHN1 |
UniProt Entry Name: | CHIN_HUMAN |