CHD2 Antibody (PACO43947)
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주문- SKU:
- PACO43947
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CHD2 Antibody (PACO43947) |
Antibody SKU: | PACO43947 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Chromodomain-helicase-DNA-binding protein 2 protein (1569-1828AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO43947 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43947 at dilution of 1:100. |
Background: | DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). |
Synonyms: | Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.12) (ATP-dependent helicase CHD2), CHD2 |
UniProt Protein Function: | CHD-2: Sequence-selective DNA-binding protein. Belongs to the SNF2/RAD54 helicase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.6.4.12; Helicase; DNA-binding Chromosomal Location of Human Ortholog: 15q26 Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nucleolus; nucleus Molecular Function:ATP-dependent DNA helicase activity; DNA binding; histone binding; ATP binding Biological Process: regulation of transcription from RNA polymerase II promoter; muscle development; transcription, DNA-dependent; chromatin modification; response to DNA damage stimulus; DNA duplex unwinding Disease: Epileptic Encephalopathy, Childhood-onset |
NCBI Summary: | The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O14647 |
NCBI GenInfo Identifier: | 119370320 |
NCBI Gene ID: | 1106 |
NCBI Accession: | O14647.2 |
UniProt Secondary Accession: | O14647,Q96IP5, C6G482, |
UniProt Related Accession: | O14647 |
Molecular Weight: | 1828 |
NCBI Full Name: | Chromodomain-helicase-DNA-binding protein 2 |
NCBI Synonym Full Names: | chromodomain helicase DNA binding protein 2 |
NCBI Official Symbol: | CHD2 |
NCBI Official Synonym Symbols: | EEOC |
NCBI Protein Information: | chromodomain-helicase-DNA-binding protein 2; CHD-2; ATP-dependent helicase CHD2 |
UniProt Protein Name: | Chromodomain-helicase-DNA-binding protein 2 |
UniProt Synonym Protein Names: | ATP-dependent helicase CHD2 |
Protein Family: | Chromodomain-helicase-DNA-binding protein |
UniProt Gene Name: | CHD2 |
UniProt Entry Name: | CHD2_HUMAN |
Antibodies |
Anti-CHD2 Antibody (CAB13476) |
Anti-CHD2 Antibody (CAB13477) |
Anti-CHD2 Antibody (CAB13478) |
Anti-CHD2 Antibody (CAB5895) |
CHD2 Antibody (PACO08398) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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