CHCHD3 Antibody (PACO45128)
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주문- SKU:
- PACO45128
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CHCHD3 Antibody (PACO45128) |
Antibody SKU: | PACO45128 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human MICOS complex subunit MIC19 protein (1-227AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: CHCHD3 antibody at 1.67µg/ml. Lane 1: Mouse lung tissue. Lane 2: HepG2 whole cell lysate. Lane 3: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 26 kDa. Observed band size: 26 kDa.. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO45128 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO45128 at dilution of 1:100. |
Background: | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. |
Synonyms: | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3), CHCHD3, MIC19 MINOS3 |
UniProt Protein Function: | CHCHD3: May be a scaffolding protein that stabilizes protein complexes involved in maintaining mitochondrial crista architecture and protein import. |
UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 7q33 Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrion; nucleus Molecular Function:phosphatase binding; protein binding; protein complex scaffold Biological Process: cristae formation; inner mitochondrial membrane organization and biogenesis; mitochondrial fusion; negative regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] |
UniProt Code: | Q9NX63 |
NCBI GenInfo Identifier: | 62510520 |
NCBI Gene ID: | 54927 |
NCBI Accession: | Q9NX63.1 |
UniProt Related Accession: | Q9NX63 |
Molecular Weight: | 26,152 Da |
NCBI Full Name: | MICOS complex subunit MIC19 |
NCBI Synonym Full Names: | coiled-coil-helix-coiled-coil-helix domain containing 3 |
NCBI Official Symbol: | CHCHD3 |
NCBI Official Synonym Symbols: | Mic19; MINOS3; PPP1R22 |
NCBI Protein Information: | MICOS complex subunit MIC19 |
UniProt Protein Name: | MICOS complex subunit MIC19 |
UniProt Synonym Protein Names: | Coiled-coil-helix-coiled-coil-helix domain-containing protein 3 |
UniProt Gene Name: | CHCHD3 |
UniProt Entry Name: | MIC19_HUMAN |