CDKN3 Antibody (PACO54694)
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주문- SKU:
- PACO54694
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CDKN3 Antibody (PACO54694) |
Antibody SKU: | PACO54694 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Cyclin-dependent kinase inhibitor 3 protein (1-172AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO54694 at dilution of 1:100. | |
Immunofluorescent analysis of PC-3 cells using PACO54694 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner. |
Synonyms: | Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase), CDKN3, CDI1 CIP2 KAP |
UniProt Protein Function: | CDKN3: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner. Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC). Belongs to the protein-tyrosine phosphatase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.16; Cell cycle regulation; EC 3.1.3.48 Chromosomal Location of Human Ortholog: 14q22 Cellular Component: perinuclear region of cytoplasm; cytoplasm Molecular Function:protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity Biological Process: negative regulation of cell proliferation; regulation of cyclin-dependent protein kinase activity; cell cycle arrest; G1/S transition of mitotic cell cycle Disease: Hepatocellular Carcinoma |
NCBI Summary: | The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
UniProt Code: | Q16667 |
NCBI GenInfo Identifier: | 2499769 |
NCBI Gene ID: | 1033 |
NCBI Accession: | Q16667.1 |
UniProt Related Accession: | Q16667 |
Molecular Weight: | 23805 Da |
NCBI Full Name: | Cyclin-dependent kinase inhibitor 3 |
NCBI Synonym Full Names: | cyclin dependent kinase inhibitor 3 |
NCBI Official Symbol: | CDKN3 |
NCBI Official Synonym Symbols: | KAP; CDI1; CIP2; KAP1 |
NCBI Protein Information: | cyclin-dependent kinase inhibitor 3 |
UniProt Protein Name: | Cyclin-dependent kinase inhibitor 3 |
UniProt Synonym Protein Names: | CDK2-associated dual-specificity phosphatase; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; Kinase-associated phosphatase |
Protein Family: | Cyclin-dependent kinase inhibitor |
UniProt Gene Name: | CDKN3 |
UniProt Entry Name: | CDKN3_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |