CDKN2C Antibody (PACO23128)
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주문- SKU:
- PACO23128
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CDKN2C Antibody (PACO23128) |
Antibody SKU: | PACO23128 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from human p18 INK antibody. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from COS7 cells, using p18 INK antibody. | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p18 INK antibody. |
Background: | Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. |
Synonyms: | OTTHUMP00000046546; p18(INK4C); p18-INK4C; CDK6 inhibitor p18; cyclin-dependent inhibitor |
UniProt Protein Function: | Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. |
NCBI Summary: | The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008] |
UniProt Code: | P42773 |
NCBI GenInfo Identifier: | 1168870 |
NCBI Gene ID: | 1031 |
NCBI Accession: | P42773.1 |
UniProt Secondary Accession: | P42773,Q8TB83, |
UniProt Related Accession: | P42773 |
Molecular Weight: | 18kDa |
NCBI Full Name: | Cyclin-dependent kinase 4 inhibitor C |
NCBI Synonym Full Names: | cyclin dependent kinase inhibitor 2C |
NCBI Official Symbol: | CDKN2C |
NCBI Official Synonym Symbols: | p18; INK4C; p18-INK4C |
NCBI Protein Information: | cyclin-dependent kinase 4 inhibitor C |
UniProt Protein Name: | Cyclin-dependent kinase 4 inhibitor C |
UniProt Synonym Protein Names: | Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6 |
Protein Family: | Cyclin-dependent kinase 4 inhibitor |
UniProt Gene Name: | CDKN2C |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |