CDH4 Antibody (PACO20327)
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주문- SKU:
- PACO20327
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CDH4 Antibody (PACO20327) |
Antibody SKU: | PACO20327 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human CDH4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane: 231 cells, Primary antibody: PACO20327(CDH4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
Background: | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. |
Synonyms: | cadherin 4, type 1, R-cadherin (retinal) |
UniProt Protein Function: | CDH4: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. Expressed mainly in brain but also found in other tissues. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 20q13.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:calcium ion binding Biological Process: heterophilic cell adhesion; intercellular junction assembly and maintenance; axon guidance; positive regulation of axon extension; cell adhesion; homophilic cell adhesion |
NCBI Summary: | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
UniProt Code: | P55283 |
NCBI GenInfo Identifier: | 81175161 |
NCBI Gene ID: | 1002 |
NCBI Accession: | P55283.2 |
UniProt Secondary Accession: | P55283,Q2M208, Q5VZ44, Q9BZ05, B3KWB8, G3V1P8, |
UniProt Related Accession: | P55283 |
Molecular Weight: | 92,388 Da |
NCBI Full Name: | Cadherin-4 |
NCBI Synonym Full Names: | cadherin 4, type 1, R-cadherin (retinal) |
NCBI Official Symbol: | CDH4 |
NCBI Official Synonym Symbols: | CAD4; RCAD; R-CAD |
NCBI Protein Information: | cadherin-4; R-cadherin; cadherin 4, type 1, preproprotein; retinal cadherin |
UniProt Protein Name: | Cadherin-4 |
UniProt Synonym Protein Names: | Retinal cadherin; R-CAD; R-cadherin |
UniProt Gene Name: | CDH4 |
UniProt Entry Name: | CADH4_HUMAN |