CDH18 Antibody (PACO53458)
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주문- SKU:
- PACO53458
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CDH18 Antibody (PACO53458) |
Antibody SKU: | PACO53458 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Cadherin-18 protein (66-251AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Mouse kidney tissue. All lanes: CDH18 antibody at 2.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 89, 64 kDa. Observed band size: 89 kDa. | |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO53458 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO53458 at dilution of 1:100. |
Background: | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
Synonyms: | Cadherin-18 (Cadherin-14), CDH18, CDH14 |
UniProt Protein Function: | CDH18: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 5p14.3 Cellular Component: integral to membrane; plasma membrane Molecular Function:calcium ion binding Biological Process: intercellular junction assembly and maintenance; homophilic cell adhesion |
NCBI Summary: | This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014] |
UniProt Code: | Q13634 |
NCBI GenInfo Identifier: | 4826671 |
NCBI Gene ID: | 1016 |
NCBI Accession: | NP_004925.1 |
UniProt Secondary Accession: | Q13634,Q8N5Z2, A8K0I2, B4DHG6, |
UniProt Related Accession: | Q13634 |
Molecular Weight: | 63,677 Da |
NCBI Full Name: | cadherin-18 isoform 1 preproprotein |
NCBI Synonym Full Names: | cadherin 18, type 2 |
NCBI Official Symbol: | CDH18 |
NCBI Official Synonym Symbols: | CDH14; CDH24; CDH14L |
NCBI Protein Information: | cadherin-18; cadherin-14; ey-cadherin; cadherin-like 24 |
UniProt Protein Name: | Cadherin-18 |
UniProt Synonym Protein Names: | Cadherin-14 |
Protein Family: | Cadherin |
UniProt Gene Name: | CDH18 |
UniProt Entry Name: | CAD18_HUMAN |