CDC34 Antibody (PACO25652)
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주문- SKU:
- PACO25652
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CDC34 Antibody (PACO25652) |
Antibody SKU: | PACO25652 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Ubiquitin-conjugating enzyme E2 R1 protein (1-236AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO25652 at dilution of 1:100. |
Background: | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIγ and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes. |
Synonyms: | Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1), CDC34, UBCH3 UBE2R1 |
UniProt Protein Function: | CDC34: a member of the ubiquitin-conjugating enzyme family. Is a part of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for ubiquitin-mediated degradation of cell cycle G1 regulators. Required for the initiation of DNA replication. |
UniProt Protein Details: | Protein type:Ligase; Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:ATP binding; protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity Biological Process: DNA replication initiation; G1/S transition of mitotic cell cycle; positive regulation of neuron apoptosis; proteasomal ubiquitin-dependent protein catabolic process; protein modification process; protein polyubiquitination; protein ubiquitination |
NCBI Summary: | The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008] |
UniProt Code: | P49427 |
NCBI GenInfo Identifier: | 2507505 |
NCBI Gene ID: | 997 |
NCBI Accession: | P49427.2 |
UniProt Secondary Accession: | P49427,A8K689, |
UniProt Related Accession: | P49427 |
Molecular Weight: | 26,737 Da |
NCBI Full Name: | Ubiquitin-conjugating enzyme E2 R1 |
NCBI Synonym Full Names: | cell division cycle 34 |
NCBI Official Symbol: | CDC34 |
NCBI Official Synonym Symbols: | UBC3; UBCH3; UBE2R1; E2-CDC34 |
NCBI Protein Information: | ubiquitin-conjugating enzyme E2 R1 |
UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 R1 |
UniProt Synonym Protein Names: | (E3-independent) E2 ubiquitin-conjugating enzyme R1 (EC:2.3.2.24 |
Protein Family: | Ubiquitin-conjugating enzyme |
UniProt Gene Name: | CDC34 |
UniProt Entry Name: | UB2R1_HUMAN |
Antibodies |
Anti-CDC34 Antibody (CAB5457) |
CDC34 Antibody (PACO00569) |
CDC34 Antibody (PACO01902) |
CDC34 Antibody (PACO08315) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |