CD79A Antibody (PACO49454)
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주문- SKU:
- PACO49454
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CD79A Antibody (PACO49454) |
Antibody SKU: | PACO49454 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human B-cell antigen receptor complex-associated protein α chain protein (70-142AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO49454 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO49454 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO49454 at dilution of 1:100. |
Background: | Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells. |
Synonyms: | B-cell antigen receptor complex-associated protein α chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a), CD79A, IGA MB1 |
UniProt Protein Function: | Ig-alpha: an integral membrane protein that associates with surface immunoglobulin B lymphocyte antigen receptor multimeric complex. Surface Ig non-covalently associates with 2 other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Immunoglobulin superfamily Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: B cell receptor complex; cytoplasm; external side of plasma membrane; integral to plasma membrane; lipid raft; multivesicular body; plasma membrane Molecular Function:protein binding Biological Process: B cell activation; B cell differentiation; B cell proliferation; B cell receptor signaling pathway Disease: Agammaglobulinemia 3, Autosomal Recessive |
NCBI Summary: | The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | P11912 |
NCBI GenInfo Identifier: | 547896 |
NCBI Gene ID: | 973 |
NCBI Accession: | P11912.2 |
UniProt Secondary Accession: | P11912,Q53FB8, A0N775, |
UniProt Related Accession: | P11912 |
Molecular Weight: | 20,786 Da |
NCBI Full Name: | B-cell antigen receptor complex-associated protein alpha chain |
NCBI Synonym Full Names: | CD79a molecule |
NCBI Official Symbol: | CD79A |
NCBI Official Synonym Symbols: | IGA; MB-1 |
NCBI Protein Information: | B-cell antigen receptor complex-associated protein alpha chain |
UniProt Protein Name: | B-cell antigen receptor complex-associated protein alpha chain |
UniProt Synonym Protein Names: | Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein; CD_antigen: CD79a |
Protein Family: | B-cell antigen receptor complex-associated protein |
UniProt Gene Name: | CD79A |
UniProt Entry Name: | CD79A_HUMAN |
Antibodies | ELISA Kits |
Anti-CD79A Antibody (CAB0331) | Human IgA / Immunoglobulin A ELISA Kit |
Anti-CD79a Antibody (CAB19024) | |
CD79A Antibody (PACO05807) | |
CD79A Antibody (PACO05808) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |