CD6 Antibody (PACO43799)
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주문- SKU:
- PACO43799
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CD6 Antibody (PACO43799) |
Antibody SKU: | PACO43799 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human T-cell differentiation antigen CD6 protein (424-668AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human thymus tissue using PACO43799 at dilution of 1:100. |
Background: | Involved in cell adhesion. Binds to CD166. |
Synonyms: | T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6], CD6 |
UniProt Protein Function: | CD6: a type I membrane protein involved in cell adhesion. Binds to CD166. Expressed on thymocytes, peripheral T cells, a subset of B cells, and a subset of neurons. Mediates the binding of developing thymocytes with thymic epithelial cells. CD6- T cells are less autoreactive than CD6+ T cells. Phosphorylated on tyrosines and serines following T cell antigen receptor signaling. Five splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q13 Cellular Component: integral to plasma membrane Molecular Function:protein binding; scavenger receptor activity Biological Process: receptor-mediated endocytosis; cell adhesion |
NCBI Summary: | This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | P30203 |
NCBI GenInfo Identifier: | 281185506 |
NCBI Gene ID: | 923 |
NCBI Accession: | P30203.3 |
UniProt Secondary Accession: | P30203,Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0, A4KAD4 A4KAD5, |
UniProt Related Accession: | P30203 |
Molecular Weight: | 60,572 Da |
NCBI Full Name: | T-cell differentiation antigen CD6 |
NCBI Synonym Full Names: | CD6 molecule |
NCBI Official Symbol: | CD6 |
NCBI Official Synonym Symbols: | TP120 |
NCBI Protein Information: | T-cell differentiation antigen CD6; T12; CD6 antigen |
UniProt Protein Name: | T-cell differentiation antigen CD6 |
UniProt Synonym Protein Names: | T12; TP120; CD_antigen: CD6 |
Protein Family: | T-cell differentiation antigen |
UniProt Gene Name: | CD6 |
UniProt Entry Name: | CD6_HUMAN |
Antibodies | ELISA Kits |
Anti-CD6 Antibody (CAB8107) | Human T-cell differentiation antigen CD6 (CD6) ELISA Kit |
CD6 Antibody (PACO02242) | |
CD6 Antibody (PACO05724) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |