CD33 Antibody (PACO43489)
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주문- SKU:
- PACO43489
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CD33 Antibody (PACO43489) |
Antibody SKU: | PACO43489 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Myeloid cell surface antigen CD33 protein (49-259AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: CD33 antibody at 8µg/ml. Lane 1: K562 whole cell lysate. Lane 2: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 40, 34, 26 kDa. Observed band size: 40 kDa. | |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43489 at dilution of 1:100. |
Background: | Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid, dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid, The sialic acid, recognition site may be masked by cis interactions with sialic acid, on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia. |
Synonyms: | Myeloid cell surface antigen CD33 (Sialic acid, binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33), CD33, SIGLEC3 |
UniProt Protein Function: | CD33: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:protein binding; receptor activity; carbohydrate binding Biological Process: negative regulation of cell proliferation; cell-cell signaling; signal transduction; cell adhesion |
UniProt Code: | P20138 |
NCBI GenInfo Identifier: | 116241290 |
NCBI Gene ID: | 945 |
NCBI Accession: | P20138.2 |
UniProt Secondary Accession: | P20138,Q8TD24, B4E3P8, C9JEN7, F8WAL2, |
UniProt Related Accession: | P20138 |
Molecular Weight: | Calculated MW: 25kDa/33kDa/39kDaObserved MW: 77kDa |
NCBI Full Name: | Myeloid cell surface antigen CD33 |
NCBI Synonym Full Names: | CD33 molecule |
NCBI Official Symbol: | CD33 |
NCBI Official Synonym Symbols: | p67; SIGLEC3; SIGLEC-3 |
NCBI Protein Information: | myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3 |
UniProt Protein Name: | Myeloid cell surface antigen CD33 |
UniProt Synonym Protein Names: | Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD_antigen: CD33 |
Protein Family: | Myeloid cell surface antigen |
UniProt Gene Name: | CD33 |
UniProt Entry Name: | CD33_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |