CD247 Antibody (PACO05714)
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주문- SKU:
- PACO05714
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CD247 Antibody (PACO05714) |
Antibody SKU: | PACO05714 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse, Rat, Monkey |
Immunogen: | Synthesized peptide derived from human CD3 zeta around the non-phosphorylation site of Y142. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | CD247; CD3Z; T3Z; TCRZ; T-cell surface glycoprotein CD3 zeta chain; T-cell receptor T3 zeta chain; CD antigen CD247 |
UniProt Protein Function: | CD3Z: a T cell surface glycoprotein that is a component of the T cell antigen receptor. Plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD3-epsilon results in impaired immune response. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q24.2 Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; integral to membrane; alpha-beta T cell receptor complex Molecular Function:identical protein binding; protein binding; protein homodimerization activity; transmembrane receptor activity Biological Process: regulation of immune response; viral reproduction; T cell costimulation; innate immune response; T cell receptor signaling pathway; regulation of defense response to virus by virus Disease: Immunodeficiency 25 |
NCBI Summary: | The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P20963 |
NCBI GenInfo Identifier: | 4557431 |
NCBI Gene ID: | 919 |
NCBI Accession: | NP_000725.1 |
UniProt Secondary Accession: | P20963,Q5VX13, Q8TAX4, B1AK49, |
UniProt Related Accession: | P20963,A46461 |
Molecular Weight: | 18,696 Da |
NCBI Full Name: | T-cell surface glycoprotein CD3 zeta chain isoform 2 |
NCBI Synonym Full Names: | CD247 molecule |
NCBI Official Symbol: | CD247 |
NCBI Official Synonym Symbols: | T3Z; CD3H; CD3Q; CD3Z; TCRZ; CD3-ZETA |
NCBI Protein Information: | T-cell surface glycoprotein CD3 zeta chain; CD3zeta chain; TCR zeta chain; CD247 antigen, zeta subunit; T-cell receptor T3 zeta chain; CD3Z antigen, zeta polypeptide (TiT3 complex); T-cell antigen receptor complex, zeta subunit of CD3 |
UniProt Protein Name: | T-cell surface glycoprotein CD3 zeta chain |
UniProt Synonym Protein Names: | T-cell receptor T3 zeta chain |
UniProt Gene Name: | CD247 |
UniProt Entry Name: | CD3Z_HUMAN |