CD200R1 Antibody (PACO43786)
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주문- SKU:
- PACO43786
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CD200R1 Antibody (PACO43786) |
Antibody SKU: | PACO43786 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Cell surface glycoprotein CD200 receptor 1 protein (226-325AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: CD200R1 antibody at 6µg/ml + Mouse lung tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 37, 22, 19, 40 kDa. Observed band size: 37 kDa. | |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO43786 at dilution of 1:100. |
Background: | Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. |
Synonyms: | Cell surface glycoprotein CD200 receptor 1 (CD200 cell surface glycoprotein receptor) (Cell surface glycoprotein OX2 receptor 1), CD200R1, CD200R CRTR2 MOX2R OX2R |
UniProt Protein Function: | CD200R: Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. Belongs to the CD200R family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 3q13.2 Cellular Component: plasma membrane; receptor complex Molecular Function:protein binding Biological Process: regulation of immune response |
NCBI Summary: | This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8TD46 |
NCBI GenInfo Identifier: | 26006823 |
NCBI Gene ID: | 131450 |
NCBI Accession: | Q8TD46.2 |
UniProt Secondary Accession: | Q8TD46,Q52LJ7, Q6IS95, Q6UW94, Q6WHB8, Q8TD44, Q8TD45 Q8TD52, B3KWZ9, E9PCM9, |
UniProt Related Accession: | Q8TD46 |
Molecular Weight: | 39,056 Da |
NCBI Full Name: | Cell surface glycoprotein CD200 receptor 1 |
NCBI Synonym Full Names: | CD200 receptor 1 |
NCBI Official Symbol: | CD200R1 |
NCBI Official Synonym Symbols: | OX2R; MOX2R; CD200R; HCRTR2 |
NCBI Protein Information: | cell surface glycoprotein CD200 receptor 1 |
UniProt Protein Name: | Cell surface glycoprotein CD200 receptor 1 |
UniProt Synonym Protein Names: | CD200 cell surface glycoprotein receptor; Cell surface glycoprotein OX2 receptor 1 |
Protein Family: | Cell surface glycoprotein CD200 receptor |
UniProt Gene Name: | CD200R1 |
UniProt Entry Name: | MO2R1_HUMAN |