CCR2 Antibody (PACO62251)
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주문- SKU:
- PACO62251
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | CCR2 Antibody (PACO62251) |
Antibody SKU: | PACO62251 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human C-C chemokine receptor type 2 protein (310-374AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescence staining of Hela cells with PACO62251 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection. |
Synonyms: | C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192), CCR2, CMKBR2 |
UniProt Protein Function: | CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: cell soma; integral to plasma membrane; perinuclear region of cytoplasm; dendrite; cytoplasm; integral to membrane; plasma membrane; perikaryon; cytosol Molecular Function:protein homodimerization activity; CCR2 chemokine receptor binding; C-C chemokine receptor activity; chemokine receptor activity Biological Process: positive regulation of T-helper 1 type immune response; viral reproduction; chemotaxis; elevation of cytosolic calcium ion concentration; response to wounding; dendritic cell chemotaxis; cellular homeostasis; inflammatory response; positive regulation of tumor necrosis factor biosynthetic process; cytokine and chemokine mediated signaling pathway; negative regulation of adenylate cyclase activity; JAK-STAT cascade; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of interferon-gamma production; negative regulation of T-helper 2 type immune response; positive regulation of interleukin-2 production; innate immune response; cellular defense response; blood vessel remodeling; positive regulation of alpha-beta T cell proliferation; immune response; positive regulation of T cell activation; negative regulation of eosinophil degranulation; positive regulation of inflammatory response |
NCBI Summary: | This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009] |
UniProt Code: | P41597 |
NCBI GenInfo Identifier: | 1168965 |
NCBI Gene ID: | 729230 |
NCBI Accession: | P41597.1 |
UniProt Secondary Accession: | P41597,Q4VBL2, A0AVQ3, B2RMT0, |
UniProt Related Accession: | P41597 |
Molecular Weight: | 41,064 Da |
NCBI Full Name: | C-C chemokine receptor type 2 |
NCBI Synonym Full Names: | chemokine (C-C motif) receptor 2 |
NCBI Official Symbol: | CCR2 |
NCBI Official Synonym Symbols: | CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2 |
NCBI Protein Information: | C-C chemokine receptor type 2; MCP-1 receptor; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor |
UniProt Protein Name: | C-C chemokine receptor type 2 |
UniProt Synonym Protein Names: | Monocyte chemoattractant protein 1 receptor; MCP-1-R; CD_antigen: CD192 |
Protein Family: | C-C chemokine receptor |
UniProt Gene Name: | CCR2 |
UniProt Entry Name: | CCR2_HUMAN |
Antibodies | ELISA Kits |
Anti-CCR2 Antibody (CAB2855) | Human C-C chemokine receptor type 2 (CCR2) ELISA Kit |
Anti-CCR2 Antibody (CAB18136) | |
CCR2 Antibody (PACO06917) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |