CCP110 Antibody (PACO44870)
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주문- SKU:
- PACO44870
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CCP110 Antibody (PACO44870) |
Antibody SKU: | PACO44870 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Centriolar coiled-coil protein of 110 kDa protein (1-280AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: CCP110 antibody at 4.6µg/ml. Lane 1: Hela whole cell lysate. Lane 2: 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 114, 112 kDa. Observed band size: 114 kDa.. | |
Immunohistochemistry of paraffin-embedded human colon tissue using PACO44870 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO44870 at dilution of 1:100. |
Background: | Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. |
Synonyms: | Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110), CCP110, CEP110 CP110 KIAA0419 |
UniProt Protein Function: | CP110: Necessary for centrosome duplication at different stages of procentriole formation. Collaborates with CEP97, being involved in the suppression of a cilia assembly program. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 16p12.3Cellular Component: centriole; centrosome; cilium; cytosol; protein complexMolecular Function: protein bindingBiological Process: cell projection organization and biogenesis; centriole replication; centrosome duplication; G2/M transition of mitotic cell cycle; regulation of cytokinesis |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | O43303 |
NCBI GenInfo Identifier: | 312222737 |
NCBI Gene ID: | 9738 |
NCBI Accession: | NP_001185951.1 |
UniProt Secondary Accession: | O43303,O43335, Q68DV9, Q8NE13, B7WP23 |
UniProt Related Accession: | O43303 |
Molecular Weight: | 111,224 Da |
NCBI Full Name: | centriolar coiled-coil protein of 110 kDa isoform 1 |
NCBI Synonym Full Names: | centriolar coiled-coil protein 110kDa |
NCBI Official Symbol: | CCP110 |
NCBI Official Synonym Symbols: | CP110; Cep110 |
NCBI Protein Information: | centriolar coiled-coil protein of 110 kDa |
UniProt Protein Name: | Centriolar coiled-coil protein of 110 kDa |
UniProt Synonym Protein Names: | Centrosomal protein of 110 kDa; CP110; Cep110 |
Protein Family: | |
UniProt Gene Name: | CCP110 |
UniProt Entry Name: | CP110_HUMAN |
Antibodies |
CCP110 Antibody (PACO05810) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |