CCNC (Ab-275) Antibody (PACO21623)
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주문- SKU:
- PACO21623
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CCNC (Ab-275) Antibody (PACO21623) |
Antibody SKU: | PACO21623 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized non-phosphopeptide derived from human Cyclin C around the phosphorylation site of serine 275 (N-G-S(p)-Q-N). |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from LOVO cells, using Cyclin C (Ab-275) antibody. |
Background: | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Li H., Genomics 32:253-259(1996). |
Synonyms: | The antiserum was produced against synthesized peptide derived from human Cyclin C.; |
UniProt Protein Function: | CCNC: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Belongs to the cyclin family. Cyclin C subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 6q21 Cellular Component: cyclin-dependent protein kinase holoenzyme complex; nucleoplasm; nucleus Molecular Function:cyclin-dependent protein kinase regulator activity; protein binding; protein serine/threonine kinase activity Biological Process: positive regulation of cyclin-dependent protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter |
NCBI Summary: | The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P24863 |
NCBI GenInfo Identifier: | 166214910 |
NCBI Gene ID: | 892 |
NCBI Accession: | P24863.2 |
UniProt Secondary Accession: | P24863,Q9H543, B4DPZ1, |
UniProt Related Accession: | P24863 |
Molecular Weight: | 22,945 Da |
NCBI Full Name: | Cyclin-C |
NCBI Synonym Full Names: | cyclin C |
NCBI Official Symbol: | CCNC |
NCBI Official Synonym Symbols: | CycC |
NCBI Protein Information: | cyclin-C |
UniProt Protein Name: | Cyclin-C |
UniProt Synonym Protein Names: | SRB11 homolog; hSRB11 |
UniProt Gene Name: | CCNC |
UniProt Entry Name: | CCNC_HUMAN |
Antibodies |
Anti-Cyclin C Antibody (CAB13610) |
Anti-Cyclin C Antibody (CAB6545) |
Phospho-CCNC (S275) Antibody (PACO05646) |
CCNC Antibody (PACO05647) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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