CCL23 Antibody (PACO19402)
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주문- SKU:
- PACO19402
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CCL23 Antibody (PACO19402) |
Antibody SKU: | PACO19402 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human CCL23 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO19402(CCL23 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human Lymphoma tissue using PACO19402(CCL23 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. |
Synonyms: | chemokine (C-C motif) ligand 23 |
UniProt Protein Function: | CCL6: Shows chemotactic activity for monocytes, resting T- lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted Chromosomal Location of Human Ortholog: 17q12 Cellular Component: extracellular space; extracellular region Molecular Function:heparin binding; CCR1 chemokine receptor binding; chemokine activity Biological Process: cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; monocyte chemotaxis; cell-cell signaling; immune response; signal transduction; chemotaxis; inflammatory response |
NCBI Summary: | This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] |
UniProt Code: | P55773 |
NCBI GenInfo Identifier: | 308153623 |
NCBI Gene ID: | 6368 |
NCBI Accession: | P55773.3 |
UniProt Secondary Accession: | P55773,O00174, O75950, Q52LD4, B7ZKQ3, |
UniProt Related Accession: | P55773 |
Molecular Weight: | 15,290 Da |
NCBI Full Name: | C-C motif chemokine 23 |
NCBI Synonym Full Names: | chemokine (C-C motif) ligand 23 |
NCBI Official Symbol: | CCL23 |
NCBI Official Synonym Symbols: | CKb8; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; hmrp-2a; CK-BETA-8 |
NCBI Protein Information: | C-C motif chemokine 23; C6 beta-chemokine; macrophage inflammatory protein 3; myeloid progenitor inhibitory factor 1; small inducible cytokine subfamily A (Cys-Cys), member 23 |
UniProt Protein Name: | C-C motif chemokine 23 |
UniProt Synonym Protein Names: | CK-beta-8; CKB-8; Macrophage inflammatory protein 3; MIP-3; Myeloid progenitor inhibitory factor 1; MPIF-1; Small-inducible cytokine A23Cleaved into the following 4 chains:CCL23(19-99); CCL23(22-99); CCL23(27-99); CCL23(30-99) |
UniProt Gene Name: | CCL23 |
UniProt Entry Name: | CCL23_HUMAN |
ELISA Kits |
Human CCL23 / MPIF-1 ELISA Kit |
Human MPIF-1/CCL23 (Myeloid Progenitor Inhibitory Factor 1) CLIA Kit (HUES00784) |
Human C-C motif chemokine 23 (CCL23) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |