CCKBR Antibody (PACO13392)
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주문- SKU:
- PACO13392
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | CCKBR Antibody (PACO13392) |
Antibody SKU: | PACO13392 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | |
Species Reactivity: | Human |
Immunogen: | Human CCKBR-specific |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | cholecystokinin B receptor;CCKBR;CCK-B;CCK2R;GASR ; |
UniProt Protein Function: | CCKBR: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral Chromosomal Location of Human Ortholog: 11p15.4 Cellular Component: cytosol; integral to plasma membrane; plasma membrane Molecular Function:1-phosphatidylinositol-3-kinase regulator activity; cholecystokinin receptor activity; gastrin receptor activity; phosphoinositide phospholipase C activity; protein binding; type B gastrin/cholecystokinin receptor binding Biological Process: cell proliferation; cell surface receptor linked signal transduction; digestion; elevation of cytosolic calcium ion concentration; feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); gastric acid secretion; gland development; gut development; positive regulation of cell proliferation; regulation of phosphoinositide 3-kinase activity; sensory perception |
NCBI Summary: | This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015] |
UniProt Code: | P32239 |
NCBI GenInfo Identifier: | 417029 |
NCBI Gene ID: | 887 |
NCBI Accession: | P32239.1 |
UniProt Secondary Accession: | P32239,O75824, Q16144, Q92492, Q96LC6, Q9NYK7, Q9UBV1 A8K7P9, |
UniProt Related Accession: | P32239 |
Molecular Weight: | 41,504 Da |
NCBI Full Name: | Gastrin/cholecystokinin type B receptor |
NCBI Synonym Full Names: | cholecystokinin B receptor |
NCBI Official Symbol: | CCKBR |
NCBI Official Synonym Symbols: | GASR; CCK-B; CCK2R |
NCBI Protein Information: | gastrin/cholecystokinin type B receptor |
UniProt Protein Name: | Gastrin/cholecystokinin type B receptor |
UniProt Synonym Protein Names: | Cholecystokinin-2 receptor; CCK2-R |
Protein Family: | Gastrin/cholecystokinin type B receptor |
UniProt Gene Name: | CCKBR |
UniProt Entry Name: | GASR_HUMAN |