CCAR2 Antibody (PACO21894)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO21894
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | CCAR2 Antibody (PACO21894) |
Antibody SKU: | PACO21894 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human KIAA1967. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from Jurkat cells, using KIAA1967 antibody. |
Background: | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Hamaguchi M., Proc. Natl. Acad. Sci. U.S.A. 99:13647-13652(2002). |
Synonyms: | Protein KIAA1967; Deleted in breast cancer gene 1 protein; DBC.1; DBC-1; p30 DBC |
UniProt Protein Function: | DBC-1: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. Component of the DBIRD complex. Interacts with ZNF326/ZIRD; the interaction is direct. Interacts (via N-terminus) with SIRT1. Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with SIRT1. Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Apoptosis; RNA-binding; Mitochondrial; Tumor suppressor Chromosomal Location of Human Ortholog: 8p22 Cellular Component: nucleoplasm; spliceosome; mitochondrial matrix; nuclear chromatin; cytoplasm; nucleus Molecular Function:enzyme inhibitor activity; protein binding; enzyme binding Biological Process: positive regulation of apoptosis; RNA splicing; rhythmic process; regulation of protein stability; cell cycle; regulation of circadian rhythm; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of catalytic activity; mitochondrial fragmentation during apoptosis; mRNA processing; regulation of RNA elongation; response to DNA damage stimulus; response to UV |
UniProt Code: | Q8N163 |
NCBI GenInfo Identifier: | 85701135 |
NCBI Gene ID: | 57805 |
NCBI Accession: | Q8N163.2 |
UniProt Secondary Accession: | Q8N163,Q6P0Q9, Q8N3G7, Q8N8M1, Q8TF34, Q9H9Q9, Q9HD12 Q9NT55, A6NL03, B2RB79, D3DSR6, |
UniProt Related Accession: | Q8N163 |
Molecular Weight: | 923 |
NCBI Full Name: | Cell cycle and apoptosis regulator protein 2 |
NCBI Synonym Full Names: | cell cycle and apoptosis regulator 2 |
NCBI Official Symbol: | CCAR2 |
NCBI Official Synonym Symbols: | DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967 |
NCBI Protein Information: | cell cycle and apoptosis regulator protein 2; p30 DBC protein; deleted in breast cancer 1; cell division cycle and apoptosis regulator protein 2 |
UniProt Protein Name: | Cell cycle and apoptosis regulator protein 2 |
UniProt Synonym Protein Names: | Cell division cycle and apoptosis regulator protein 2; DBIRD complex subunit KIAA1967; Deleted in breast cancer gene 1 protein; DBC-1; DBC.1; p30 DBC |
Protein Family: | Cell cycle and apoptosis regulator protein |
UniProt Gene Name: | CCAR2 |
UniProt Entry Name: | CCAR2_HUMAN |