CBLIF Antibody (PACO26977)
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주문- SKU:
- PACO26977
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CBLIF Antibody (PACO26977) |
Antibody SKU: | PACO26977 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Cobalamin binding intrinsic factor protein (19-417AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human lung tissue using PACO26977 at dilution of 1:100. |
Background: | Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis. |
Synonyms: | Cobalamin binding intrinsic factor (Gastric intrinsic factor) (Intrinsic factor) (IF) (INF), CBLIF, GIF, IFMH |
UniProt Protein Function: | GIF: Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis. Defects in GIF are the cause of hereditary intrinsic factor deficiency (IFD); also known as congenital pernicious anemia. IFD is an autosomal recessive disorder characterized by megaloblastic anemia. Belongs to the eukaryotic cobalamin transport proteins family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q13 Cellular Component: extracellular space; lysosomal lumen; microvillus; apical plasma membrane; extracellular region; endosome Molecular Function:cobalamin binding Biological Process: vitamin metabolic process; cobalamin metabolic process; cobalamin transport; cobalt ion transport; water-soluble vitamin metabolic process Disease: Intrinsic Factor Deficiency |
NCBI Summary: | This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008] |
UniProt Code: | P27352 |
NCBI GenInfo Identifier: | 62906845 |
NCBI Gene ID: | 2694 |
NCBI Accession: | P27352.2 |
UniProt Related Accession: | P27352 |
Molecular Weight: | |
NCBI Full Name: | Cobalamin binding intrinsic factor |
NCBI Synonym Full Names: | cobalamin binding intrinsic factor |
NCBI Official Symbol: | CBLIF |
NCBI Official Synonym Symbols: | IF; GIF; INF; IFMH; TCN3 |
NCBI Protein Information: | cobalamin binding intrinsic factor |
UniProt Protein Name: | Gastric intrinsic factor |
UniProt Synonym Protein Names: | Intrinsic factor; IF; INF |
Protein Family: | Gastric intrinsic factor |
UniProt Gene Name: | GIF |
UniProt Entry Name: | IF_HUMAN |
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