CARD8 Antibody (PACO15933)
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주문- SKU:
- PACO15933
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CARD8 Antibody (PACO15933) |
Antibody SKU: | PACO15933 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human CARD8 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15933(CARD8 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15933(CARD8 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. |
Synonyms: | caspase recruitment domain family, member 8 |
UniProt Protein Function: | CARD8: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Inhibitor; Apoptosis Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:protein binding; NACHT domain binding; protein homodimerization activity; caspase activator activity Biological Process: caspase activation; positive regulation of caspase activity; negative regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-1 beta secretion |
NCBI Summary: | The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010] |
UniProt Code: | Q9Y2G2 |
NCBI GenInfo Identifier: | 14424229 |
NCBI Gene ID: | 22900 |
NCBI Accession: | Q9Y2G2.1 |
UniProt Secondary Accession: | Q9Y2G2,Q6PGP8, Q96P82, B5KVR6, B7Z496, B7Z4A2, E9PEM7 G3XAM9, |
UniProt Related Accession: | Q9Y2G2 |
Molecular Weight: | 60,652 Da |
NCBI Full Name: | Caspase recruitment domain-containing protein 8 |
NCBI Synonym Full Names: | caspase recruitment domain family, member 8 |
NCBI Official Symbol: | CARD8 |
NCBI Official Synonym Symbols: | NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL |
NCBI Protein Information: | caspase recruitment domain-containing protein 8; apoptotic protein NDPP1; CARD inhibitor of NF-kappaB-activating ligands; tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine |
UniProt Protein Name: | Caspase recruitment domain-containing protein 8 |
UniProt Synonym Protein Names: | Apoptotic protein NDPP1; CARD-inhibitor of NF-kappa-B-activating ligand; CARDINAL; DACAR; Tumor up-regulated CARD-containing antagonist of CASP9; TUCAN |
Protein Family: | Caspase recruitment domain-containing protein |
UniProt Gene Name: | CARD8 |
UniProt Entry Name: | CARD8_HUMAN |