CARD11 Antibody (PACO44044)
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주문- SKU:
- PACO44044
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | CARD11 Antibody (PACO44044) |
Antibody SKU: | PACO44044 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Caspase recruitment domain-containing protein 11 protein (985-1154AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: CARD11 antibody at 4µg/ml + K562 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 133 kDa. Observed band size: 133 kDa.. |
Background: | Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. |
Synonyms: | Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1), CARD11, CARMA1 |
UniProt Protein Function: | CARD11: a CARD (caspase recruitment domain) protein that belongs to the membrane-associated guanylate kinase (MAGUK) family. MAGUK proteins function as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. Contains an N-terminal CARD domain, a central coiled-coil domain, and a C-terminal region containing a PDZ, an SH3, and a GUK. Its CARD domain associates with the CARD domain of BCL10. BCL10 activates NF-kappaB through the IkappaB kinase complex in response to upstream stimuli. Apparently activates NF-kappaB and induce the phosphorylation of BCL10. Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 7p22 Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; immunological synapse; cytosol; lipid raft Molecular Function:guanylate kinase activity; protein binding; CARD domain binding Biological Process: positive regulation of cytokine production; thymic T cell selection; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-2 biosynthetic process; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; regulation of apoptosis; regulation of B cell differentiation; T cell costimulation; positive regulation of B cell proliferation; innate immune response; regulation of T cell differentiation; positive regulation of T cell proliferation; nucleotide phosphorylation Disease: Persistent Polyclonal B-cell Lymphocytosis; Immunodeficiency 11; B-cell Expansion With Nfkb And T-cell Anergy |
NCBI Summary: | The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9BXL7 |
NCBI GenInfo Identifier: | 172046231 |
NCBI Gene ID: | 84433 |
NCBI Accession: | Q9BXL7.3 |
UniProt Secondary Accession: | Q9BXL7,Q2NKN7, Q548H3, A4D1Z7, |
UniProt Related Accession: | Q9BXL7 |
Molecular Weight: | 133,284 Da |
NCBI Full Name: | Caspase recruitment domain-containing protein 11 |
NCBI Synonym Full Names: | caspase recruitment domain family, member 11 |
NCBI Official Symbol: | CARD11 |
NCBI Official Synonym Symbols: | PPBL; BENTA; BIMP3; IMD11; CARMA1 |
NCBI Protein Information: | caspase recruitment domain-containing protein 11; carma 1; CARD-containing MAGUK protein 1; bcl10-interacting maguk protein 3 |
UniProt Protein Name: | Caspase recruitment domain-containing protein 11 |
UniProt Synonym Protein Names: | CARD-containing MAGUK protein 1; Carma 1 |
Protein Family: | Caspase recruitment domain-containing protein |
UniProt Gene Name: | CARD11 |
UniProt Entry Name: | CAR11_HUMAN |