CAPNS1 Antibody (PACO14155)
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주문- SKU:
- PACO14155
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CAPNS1 Antibody (PACO14155) |
Antibody SKU: | PACO14155 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human CAPNS1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO14155(CAPNS1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 12%SDS-PAGE, Lysate: 60 μg, Lane 1-2: K562 cells, NIH/3T3 cells, Primary antibody: PACO14155(CAPNS1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO14155(CAPNS1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene. |
Synonyms: | calpain, small subunit 1 |
UniProt Protein Function: | CAPNS1: Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. |
UniProt Protein Details: | Protein type:Protease; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 19q13.12 Cellular Component: membrane; cytoplasm; plasma membrane; cytosol Molecular Function:protein binding; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; positive regulation of cell proliferation; proteolysis |
NCBI Summary: | This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] |
UniProt Code: | P04632 |
NCBI GenInfo Identifier: | 115612 |
NCBI Gene ID: | 826 |
NCBI Accession: | P04632.1 |
UniProt Related Accession: | P04632 |
Molecular Weight: | 28kDa |
NCBI Full Name: | Calpain small subunit 1 |
NCBI Synonym Full Names: | calpain small subunit 1 |
NCBI Official Symbol: | CAPNS1 |
NCBI Official Synonym Symbols: | CANP; CDPS; CSS1; CANPS; CAPN4; CALPAIN4 |
NCBI Protein Information: | calpain small subunit 1 |
UniProt Protein Name: | Calpain small subunit 1 |
UniProt Synonym Protein Names: | Calcium-activated neutral proteinase small subunit; CANP small subunit; Calcium-dependent protease small subunit; CDPS; Calcium-dependent protease small subunit 1; Calpain regulatory subunit |
Protein Family: | Calpain |
UniProt Gene Name: | CAPNS1 |
UniProt Entry Name: | CPNS1_HUMAN |