CALCOCO2 Antibody (PACO44614)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO44614
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CALCOCO2 Antibody (PACO44614) |
Antibody SKU: | PACO44614 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IP |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Calcium-binding and coiled-coil domain-containing protein 2 protein (137-446AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: CALCOCO2 antibody at 3.66µg/ml. Lane 1: Hela whole cell lysate. Lane 2: Jurkat whole cell lysate. Lane 3: 293T whole cell lysate. Lane 4: Raji whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 53, 48, 55, 56, 44 kDa. Observed band size: 56 kDa.. | |
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO44614 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO44614 at dilution of 1:100. |
Background: | Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion. |
Synonyms: | Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52), CALCOCO2, NDP52 |
UniProt Protein Function: | CALCOCO2: May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion. Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6. Interacts with GEMIN4. Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain. |
UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 17q21.32 Cellular Component: Golgi apparatus; cytoskeleton; intracellular membrane-bound organelle; membrane; perinuclear region of cytoplasm; cytoplasm; nucleus Molecular Function:protein binding; protein homodimerization activity Biological Process: viral reproduction |
NCBI Summary: | This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] |
UniProt Code: | Q13137 |
NCBI GenInfo Identifier: | 74735623 |
NCBI Gene ID: | 10241 |
NCBI Accession: | Q13137.1 |
UniProt Secondary Accession: | Q13137,Q53FQ5, Q53HB5, Q6IBN9, B2RBT0, B4DDC4, B4DDT4 B4DP36, B4E0C0, E7ENK0, E7ETP5, E9PBE5, |
UniProt Related Accession: | Q13137 |
Molecular Weight: | 446 |
NCBI Full Name: | Calcium-binding and coiled-coil domain-containing protein 2 |
NCBI Synonym Full Names: | calcium binding and coiled-coil domain 2 |
NCBI Official Symbol: | CALCOCO2 |
NCBI Official Synonym Symbols: | NDP52 |
NCBI Protein Information: | calcium-binding and coiled-coil domain-containing protein 2; nuclear dot protein 52; nuclear domain 10 protein 52; nuclear domain 10 protein NDP52; antigen nuclear dot 52 kDa protein |
UniProt Protein Name: | Calcium-binding and coiled-coil domain-containing protein 2 |
UniProt Synonym Protein Names: | Antigen nuclear dot 52 kDa protein; Nuclear domain 10 protein NDP52; Nuclear domain 10 protein 52; Nuclear dot protein 52 |
Protein Family: | Calcium-binding and coiled-coil domain-containing protein |
UniProt Gene Name: | CALCOCO2 |
UniProt Entry Name: | CACO2_HUMAN |
Antibodies | ELISA Kits |
Anti-CALCOCO2 Antibody (CAB7358) | Human CALCOCO2 (Calcium-binding and coiled-coil domain-containing protein 2) ELISA Kit (HUFI04600) |
CALCOCO2 Antibody (PACO08145) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |