CABLES1 Antibody (PACO22016)
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주문- SKU:
- PACO22016
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CABLES1 Antibody (PACO22016) |
Antibody SKU: | PACO22016 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from internal of human Ik3-1. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from LOVO cells, using Ik3-1 antibody. |
Background: | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death By similarity. |
Synonyms: | Cdk5 and Abl enzyme substrate 1; FLJ35924; |
UniProt Protein Function: | CABLES1: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death. Belongs to the cyclin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 18q11.2 Cellular Component: cytosol Molecular Function:protein binding |
NCBI Summary: | This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
UniProt Code: | Q8TDN4 |
NCBI GenInfo Identifier: | 73921298 |
NCBI Gene ID: | 91768 |
NCBI Accession: | Q8TDN4.2 |
UniProt Secondary Accession: | Q8TDN4,Q8N3Y8, Q8NA22, Q9BTG1, B4DK60, |
UniProt Related Accession: | Q8TDN4 |
Molecular Weight: | 68kDa |
NCBI Full Name: | CDK5 and ABL1 enzyme substrate 1 |
NCBI Synonym Full Names: | Cdk5 and Abl enzyme substrate 1 |
NCBI Official Symbol: | CABLES1 |
NCBI Official Synonym Symbols: | CABL1; IK3-1; CABLES; HsT2563 |
NCBI Protein Information: | CDK5 and ABL1 enzyme substrate 1 |
UniProt Protein Name: | CDK5 and ABL1 enzyme substrate 1 |
UniProt Synonym Protein Names: | Interactor with CDK3 1; Ik3-1 |
Protein Family: | CDK5 and ABL1 enzyme substrate |
UniProt Gene Name: | CABLES1 |