C6 Antibody (PACO49434)
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주문- SKU:
- PACO49434
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | C6 Antibody (PACO49434) |
Antibody SKU: | PACO49434 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Recombinant Human Complement component C6 protein (521-655AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Rat liver tissue, Mouse kidney tissue. All lanes: C6 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 105 kDa. Observed band size: 105 kDa.. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO49434 at dilution of 1:100. |
Background: | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. |
Synonyms: | Complement component C6, C6 |
UniProt Protein Function: | C6: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C6 are the cause of complement component 6 deficiency (C6D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5p13.1 Cellular Component: extracellular region; membrane attack complex Molecular Function:protein binding Biological Process: complement activation; regulation of complement activation Disease: Complement Component 6 Deficiency |
NCBI Summary: | This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012] |
UniProt Code: | P13671 |
NCBI GenInfo Identifier: | 146345396 |
NCBI Gene ID: | 729 |
NCBI Accession: | P13671.3 |
UniProt Related Accession: | P13671 |
Molecular Weight: | 104,786 Da |
NCBI Full Name: | Complement component C6 |
NCBI Synonym Full Names: | complement C6 |
NCBI Official Symbol: | C6 |
NCBI Protein Information: | complement component C6 |
UniProt Protein Name: | Complement component C6 |
Protein Family: | Complement component |
UniProt Gene Name: | C6 |
Antibodies | ELISA Kits |
Anti-C6 Antibody (CAB10170) | Human C6(Complement C6) ELISA Kit |
C6 Antibody (PACO00487) | Human Complement component C6 (C6) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |