C1QA Antibody (PACO51362)
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주문- SKU:
- PACO51362
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | C1QA Antibody (PACO51362) |
Antibody SKU: | PACO51362 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Complement C1q subcomponent subunit A protein (26-125AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO51362 at dilution of 1:100. | |
Immunofluorescent analysis of Hela cells using PACO51362 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO51362 at dilution of 1:100. |
Background: | C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. |
Synonyms: | Complement C1q subcomponent subunit A, C1QA |
UniProt Protein Function: | C1QA iso2: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2 )-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p36.12 Cellular Component: complement component C1 complex; extracellular region Molecular Function:protein binding; serine-type endopeptidase activity Biological Process: cell-cell signaling; complement activation; complement activation, classical pathway Disease: C1q Deficiency |
NCBI Summary: | This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008] |
UniProt Code: | P02745 |
NCBI GenInfo Identifier: | 399138 |
NCBI Gene ID: | 712 |
NCBI Accession: | P02745.2 |
UniProt Secondary Accession: | P02745,Q5T963, B2R4X2, |
UniProt Related Accession: | P02745 |
Molecular Weight: | 26,017 Da |
NCBI Full Name: | Complement C1q subcomponent subunit A |
NCBI Synonym Full Names: | complement C1q A chain |
NCBI Official Symbol: | C1QA |
NCBI Protein Information: | complement C1q subcomponent subunit A |
UniProt Protein Name: | Complement C1q subcomponent subunit A |
Protein Family: | Complement C1q subcomponent |
UniProt Gene Name: | C1QA |
UniProt Entry Name: | C1QA_HUMAN |
Antibodies | ELISA Kits |
Anti-C1QA Antibody (CAB13659) | Human C1qR / CD93 ELISA Kit |
Anti-C1QA Antibody (CAB1821) | Human Complement C1q subcomponent subunit A (C1QA) ELISA Kit |
C1QA Antibody (PACO08095) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |