C1D Antibody (PACO31688)
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주문- SKU:
- PACO31688
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | C1D Antibody (PACO31688) |
Antibody SKU: | PACO31688 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:2000-1:10000, IHC:1:50-1:500, IF:1:500-1:1000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Nuclear nucleic acid, binding protein C1D protein (1-135AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot Positive WB detected in: Hela whole cell lysate All lanes: C1D antibody at 3.2µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 17 kDa Observed band size: 17 kDa . | |
Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO31688 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO31688 at dilution of 1:100. |
Background: | Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. |
Synonyms: | Nuclear nucleic acid, binding protein C1D (hC1D), C1D |
UniProt Protein Function: | C1D: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. Belongs to the C1D family. |
UniProt Protein Details: | Protein type:Nucleolus; DNA-binding; Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 2p13-p12 Cellular Component: transcriptional repressor complex; cytoplasm; nucleolus; nucleus; nuclear exosome (RNase complex) Molecular Function:ligand-dependent nuclear receptor binding; protein binding; DNA binding; RNA binding; transcription corepressor activity Biological Process: maturation of 5.8S rRNA; transcription, DNA-dependent; apoptosis; negative regulation of transcription, DNA-dependent |
NCBI Summary: | The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010] |
UniProt Code: | Q13901 |
NCBI GenInfo Identifier: | 74754472 |
NCBI Gene ID: | 10438 |
NCBI Accession: | Q13901.1 |
UniProt Secondary Accession: | Q13901,Q05D64, A8K336, D6W5F8, |
UniProt Related Accession: | Q13901 |
Molecular Weight: | 141 |
NCBI Full Name: | Nuclear nucleic acid-binding protein C1D |
NCBI Synonym Full Names: | C1D nuclear receptor corepressor |
NCBI Official Symbol: | C1D |
NCBI Official Synonym Symbols: | LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR |
NCBI Protein Information: | nuclear nucleic acid-binding protein C1D; C1D DNA-binding protein; nuclear DNA-binding protein; C1D nuclear receptor co-repressor; small unique nuclear receptor corepressor; small unique nuclear receptor co-repressor |
UniProt Protein Name: | Nuclear nucleic acid-binding protein C1D |
Protein Family: | Nuclear nucleic acid-binding protein |
UniProt Gene Name: | C1D |
UniProt Entry Name: | C1D_HUMAN |