BMP15 Antibody (PACO15879)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO15879
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | BMP15 Antibody (PACO15879) |
Antibody SKU: | PACO15879 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human BMP15 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO15879(BMP15 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: A549 cells, Primary antibody: PACO15879(BMP15 Antibody) at dilution 1/266.7, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15879(BMP15 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-β superfamily. The transforming growth factor-β superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9. Defects in this gene are the cause of ovarian dysgenesis 2. |
Synonyms: | bone morphogenetic protein 15 |
UniProt Protein Function: | BMP15: May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2); also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea. Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4). An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. Belongs to the TGF-beta family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cytokine Chromosomal Location of Human Ortholog: Xp11.2 Cellular Component: extracellular space; cytoplasm Molecular Function:growth factor activity; cytokine activity; transforming growth factor beta receptor binding Biological Process: BMP signaling pathway; regulation of apoptosis; granulosa cell development; ovarian follicle development; positive regulation of transcription, DNA-dependent; regulation of MAPKKK cascade; female gamete generation; cell development Disease: Ovarian Dysgenesis 2 |
NCBI Summary: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016] |
UniProt Code: | O95972 |
NCBI GenInfo Identifier: | 51338749 |
NCBI Gene ID: | 9210 |
NCBI Accession: | O95972.2 |
UniProt Related Accession: | O95972 |
Molecular Weight: | |
NCBI Full Name: | Bone morphogenetic protein 15 |
NCBI Synonym Full Names: | bone morphogenetic protein 15 |
NCBI Official Symbol: | BMP15 |
NCBI Official Synonym Symbols: | ODG2; POF4; GDF9B |
NCBI Protein Information: | bone morphogenetic protein 15 |
UniProt Protein Name: | Bone morphogenetic protein 15 |
UniProt Synonym Protein Names: | Growth/differentiation factor 9B |
Protein Family: | Bone morphogenetic protein |
UniProt Gene Name: | BMP15 |
UniProt Entry Name: | BMP15_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |