BMF Antibody (PACO43041)
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주문- SKU:
- PACO43041
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | BMF Antibody (PACO43041) |
Antibody SKU: | PACO43041 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Bcl-2-modifying factor protein (1-184AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO43041 at dilution of 1:100. |
Background: | May play a role in apoptosis. Isoform 1 seems to be the main initiator. |
Synonyms: | Bcl-2-modifying factor, BMF |
UniProt Protein Function: | BMF: May play a role in apoptosis. Isoform 1 seems to be the main initiator. Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2. Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. Belongs to the Bcl-2 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis; Cytoskeletal Chromosomal Location of Human Ortholog: 15q14 Cellular Component: mitochondrial outer membrane; plasma membrane; acrosome; cytosol; myosin complex Molecular Function:protein binding Biological Process: positive regulation of protein homooligomerization; apoptosis; anoikis |
NCBI Summary: | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q96LC9 |
NCBI GenInfo Identifier: | 56748563 |
NCBI Gene ID: | 90427 |
NCBI Accession: | Q96LC9.1 |
UniProt Secondary Accession: | Q96LC9,Q2M396, Q6NT30, Q6NT56, Q6P9F6, Q7Z7D4, Q7Z7D5 Q9H7K7, |
UniProt Related Accession: | Q96LC9 |
Molecular Weight: | 184 |
NCBI Full Name: | Bcl-2-modifying factor |
NCBI Synonym Full Names: | Bcl2 modifying factor |
NCBI Official Symbol: | BMF |
NCBI Protein Information: | bcl-2-modifying factor |
UniProt Protein Name: | Bcl-2-modifying factor |
Protein Family: | Bcl-2-modifying factor |
UniProt Gene Name: | BMF |
UniProt Entry Name: | BMF_HUMAN |
Antibodies | ELISA Kits |
Anti-BMF Antibody (CAB12907) | Human BMF / Bcl2 Modifying Factor ELISA Kit |
Anti-BMF Antibody (CAB5796) | Human BMF (Bcl-2 Modifying Factor) ELISA Kit (HUES01747) |
BMF Antibody (PACO08025) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |