BID Antibody (PACO14133)
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주문- SKU:
- PACO14133
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | BID Antibody (PACO14133) |
Antibody SKU: | PACO14133 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:200-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human BID |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 12%SDS-PAGE, Lysate: 30 μg, Lane 1-3: Human fetal brain tissue, HT29 cells, HepG2 cells, Primary antibody: PACO14133(BID Antibody) at dilution 1/220, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human renal cancer tissue using PACO14133(BID Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. |
Synonyms: | BH3-interacting domain death agonist |
UniProt Protein Function: | BID: a pro-apoptotic member of the Bcl-2 superfamily. Targets intracellular membranes and contains a BH3 death domain. Heterodimerizes with either the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2, antagonizing its protective effect. The activity of BID is regulated by Caspase 8-mediated cleavage, exposing the BH3 domain and significantly changing the surface charge and hydrophobicity, causing translocation to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced variants have been found. |
UniProt Protein Details: | Protein type:Mitochondrial; Apoptosis Chromosomal Location of Human Ortholog: 22q11.1 Cellular Component: cytosol; membrane; mitochondrial outer membrane; mitochondrion Molecular Function:death receptor binding; protein binding Biological Process: apoptotic mitochondrial changes; DNA damage response, signal transduction; induction of apoptosis via death domain receptors; neuron apoptosis; positive regulation of apoptosis; positive regulation of protein homooligomerization; positive regulation of protein oligomerization; regulation of apoptosis; release of cytochrome c from mitochondria |
NCBI Summary: | This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008] |
UniProt Code: | P55957 |
NCBI GenInfo Identifier: | 2493285 |
NCBI Gene ID: | 637 |
NCBI Accession: | P55957.1 |
UniProt Secondary Accession: | P55957,Q549M7, Q71T04, Q7Z4M9, Q8IY86, |
UniProt Related Accession: | P55957 |
Molecular Weight: | 11,263 Da |
NCBI Full Name: | BH3-interacting domain death agonist |
NCBI Synonym Full Names: | BH3 interacting domain death agonist |
NCBI Official Symbol: | BID |
NCBI Official Synonym Symbols: | FP497 |
NCBI Protein Information: | BH3-interacting domain death agonist |
UniProt Protein Name: | BH3-interacting domain death agonist |
UniProt Synonym Protein Names: | p22 BID; BID |
Protein Family: | BH3-interacting domain death agonist |
UniProt Gene Name: | BID |
UniProt Entry Name: | BID_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |