BCL11B Antibody (PACO47130)
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주문- SKU:
- PACO47130
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | BCL11B Antibody (PACO47130) |
Antibody SKU: | PACO47130 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human B-cell lymphoma/leukemia 11B protein (500-550AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO47130 at dilution of 1:300. |
Background: | Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). |
Synonyms: | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1), BCL11B, CTIP2 RIT1 |
UniProt Protein Function: | Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element. |
NCBI Summary: | This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013] |
UniProt Code: | Q9C0K0 |
NCBI GenInfo Identifier: | 44887723 |
NCBI Gene ID: | 64919 |
NCBI Accession: | Q9C0K0.1 |
UniProt Secondary Accession: | Q9C0K0,Q9H162, |
UniProt Related Accession: | Q9C0K0 |
Molecular Weight: | 88,476 Da |
NCBI Full Name: | B-cell lymphoma/leukemia 11B |
NCBI Synonym Full Names: | B-cell CLL/lymphoma 11B |
NCBI Official Symbol: | BCL11B |
NCBI Official Synonym Symbols: | ATL1; RIT1; CTIP2; CTIP-2; ZNF856B; ATL1-beta; ATL1-alpha; ATL1-delta; ATL1-gamma; hRIT1-alpha |
NCBI Protein Information: | B-cell lymphoma/leukemia 11B |
UniProt Protein Name: | B-cell lymphoma/leukemia 11B |
UniProt Synonym Protein Names: | B-cell CLL/lymphoma 11B; COUP-TF-interacting protein 2; Radiation-induced tumor suppressor gene 1 protein; hRit1 |
Protein Family: | B-cell lymphoma/leukemia |
UniProt Gene Name: | BCL11B |
UniProt Entry Name: | BC11B_HUMAN |