BCAS2 Antibody (PACO15852)
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주문- SKU:
- PACO15852
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | BCAS2 Antibody (PACO15852) |
Antibody SKU: | PACO15852 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human BCAS2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15852(BCAS2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A172 cells, 231 cells, Primary antibody: PACO15852(BCAS2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15852(BCAS2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | BCAS2 (breast carcinoma amplified sequence 2), also designated DAM1 (DNA amplified in mammary carcinoma 1 protein) or spliceosome-associated SPF 27, is a ubiquitously expressed nuclear protein that was originally identified as being overexpressed in various breast cancer cell lines. BCAS2 is now known to be a component of the spliceosome, participating in the removal of introns from mRNA precursors. BCAS2 specifically interacts (in a ligand-independent manner) with TR ∫ (thyroid hormone receptor beta), ER (estrogen receptor alpha), ER ∫, PR (progesterone receptor), and PPAR (Peroxisome proliferator-activated receptor gamma). BCAS2 functions as an ER coactivator and is capable of enhancing ER-mediated transcription. This suggests that BCAS2 is involved in the development of breast cancer. |
Synonyms: | breast carcinoma amplified sequence 2 |
UniProt Protein Function: | BCAS2: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Belongs to the SPF27 family. |
UniProt Protein Details: | Protein type:Nucleolus; RNA splicing; Spliceosome; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 1p13.2 Cellular Component: nucleoplasm; spliceosome; DNA replication factor A complex; nucleolus; nucleus; cell junction Molecular Function:protein binding Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; RNA splicing; gene expression |
UniProt Code: | O75934 |
NCBI GenInfo Identifier: | 71153839 |
NCBI Gene ID: | 10286 |
NCBI Accession: | O75934.1 |
UniProt Secondary Accession: | O75934,Q6FGS0, |
UniProt Related Accession: | O75934 |
Molecular Weight: | 225 |
NCBI Full Name: | Pre-mRNA-splicing factor SPF27 |
NCBI Synonym Full Names: | breast carcinoma amplified sequence 2 |
NCBI Official Symbol: | BCAS2 |
NCBI Official Synonym Symbols: | DAM1; SPF27; Snt309 |
NCBI Protein Information: | pre-mRNA-splicing factor SPF27; breast carcinoma-amplified sequence 2; spliceosome-associated protein SPF 27; DNA amplified in mammary carcinoma 1 protein; spliceosome associated protein, amplified in breast cancer |
UniProt Protein Name: | Pre-mRNA-splicing factor SPF27 |
UniProt Synonym Protein Names: | Breast carcinoma-amplified sequence 2; DNA amplified in mammary carcinoma 1 protein; Spliceosome-associated protein SPF 27 |
UniProt Gene Name: | BCAS2 |
UniProt Entry Name: | SPF27_HUMAN |