BAZ2A Antibody (PACO22211)
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주문- SKU:
- PACO22211
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | BAZ2A Antibody (PACO22211) |
Antibody SKU: | PACO22211 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human BAZ2A. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from Jurkat cells, using BAZ2A antibody. |
Background: | Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing By similarity. |
Synonyms: | BA2A; BAZ2A; bromodomain adjacent to zinc finger domain 2A; hWALp3; KIAA0314 |
UniProt Protein Function: | Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing. |
UniProt Code: | Q9UIF9 |
NCBI GenInfo Identifier: | 91176325 |
NCBI Gene ID: | 11176 |
NCBI Accession: | NP_038477.2 |
UniProt Secondary Accession: | Q9UIF9,O00536, O15030, Q68DI8, Q96H26, B3KN66, |
UniProt Related Accession: | Q9UIF9 |
Molecular Weight: | 210,747 Da |
NCBI Full Name: | bromodomain adjacent to zinc finger domain protein 2A isoform 1 |
NCBI Synonym Full Names: | bromodomain adjacent to zinc finger domain 2A |
NCBI Official Symbol: | BAZ2A |
NCBI Official Synonym Symbols: | TIP5; WALp3 |
NCBI Protein Information: | bromodomain adjacent to zinc finger domain protein 2A |
UniProt Protein Name: | Bromodomain adjacent to zinc finger domain protein 2A |
UniProt Synonym Protein Names: | Transcription termination factor I-interacting protein 5; TTF-I-interacting protein 5; Tip5; hWALp3 |
UniProt Gene Name: | BAZ2A |