BACE1 Antibody (PACO14122)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO14122
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | BACE1 Antibody (PACO14122) |
Antibody SKU: | PACO14122 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:15-1:50 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human BACE1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO14122(BACE1 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14122(BACE1 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | Cerebral deposition of amyloid β peptide is an early and critical feature of Alzheimer's disease. Amyloid β peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. |
Synonyms: | beta-site APP-cleaving enzyme 1 |
UniProt Protein Function: | BACE: an integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Cleaves APP at the amino terminus of the A-beta peptide sequence, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment which is later release by gamma-secretase. Four splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:EC 3.4.23.46; Membrane protein, integral; Protease Chromosomal Location of Human Ortholog: 11q23.2-q23.3 Cellular Component: endoplasmic reticulum lumen; endosome; endosome membrane; Golgi apparatus; integral to plasma membrane; late endosome; multivesicular body; plasma membrane; trans-Golgi network Molecular Function:aspartic-type endopeptidase activity; beta-amyloid binding; beta-aspartyl-peptidase activity; enzyme binding; peptidase activity; protein binding Biological Process: beta-amyloid metabolic process; cellular protein metabolic process; membrane protein ectodomain proteolysis; protein catabolic process; proteolysis |
NCBI Summary: | This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015] |
UniProt Code: | P56817 |
NCBI GenInfo Identifier: | 296434407 |
NCBI Gene ID: | 23621 |
NCBI Accession: | P56817.2 |
UniProt Secondary Accession: | P56817,Q9BYB9, Q9BYC0, Q9BYC1, Q9UJT5, Q9ULS1, A0M8W7 B0YIU9, E9PE65, H7BXJ9, |
UniProt Related Accession: | P56817 |
Molecular Weight: | 42,107 Da |
NCBI Full Name: | Beta-secretase 1 |
NCBI Synonym Full Names: | beta-secretase 1 |
NCBI Official Symbol: | BACE1 |
NCBI Official Synonym Symbols: | ASP2; BACE; HSPC104 |
NCBI Protein Information: | beta-secretase 1 |
UniProt Protein Name: | Beta-secretase 1 |
UniProt Synonym Protein Names: | Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2 |
Protein Family: | Beta-secretase |
UniProt Gene Name: | BACE1 |
UniProt Entry Name: | BACE1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |