AZI2 Antibody (PACO56154)
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주문- SKU:
- PACO56154
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | AZI2 Antibody (PACO56154) |
Antibody SKU: | PACO56154 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human 5-azacytidine-induced protein 2 protein (258-376AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO56154 diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
Immunofluorescence staining of Hela cells with PACO56154 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
IHC image of PACO56154 diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-α or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. |
Synonyms: | 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (TILP), AZI2, NAP1 TBKBP2 |
UniProt Protein Function: | AZI2: Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFN-beta promoter activation via TICAM1. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 3p24.1 Cellular Component: cytoplasm Molecular Function:protein binding Biological Process: tumor necrosis factor production; I-kappaB kinase/NF-kappaB cascade; T cell activation; interleukin-6 production; interferon-gamma production; mitotic cell cycle; interferon-alpha production |
NCBI Summary: | AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q9H6S1 |
NCBI GenInfo Identifier: | 11968003 |
NCBI Gene ID: | 64343 |
NCBI Accession: | NP_071906.1 |
UniProt Secondary Accession: | Q9H6S1,Q86W99, Q9BQF1, A8K3M2, |
UniProt Related Accession: | Q9H6S1 |
Molecular Weight: | 44,935 Da |
NCBI Full Name: | 5-azacytidine-induced protein 2 isoform a |
NCBI Synonym Full Names: | 5-azacytidine induced 2 |
NCBI Official Symbol: | AZI2 |
NCBI Official Synonym Symbols: | AZ2; NAP1; TILP |
NCBI Protein Information: | 5-azacytidine-induced protein 2; NAK-associated protein 1; 5-azacytidine induced gene 2; NF-kappa-B-activating kinase-associated protein 1 |
UniProt Protein Name: | 5-azacytidine-induced protein 2 |
UniProt Synonym Protein Names: | NF-kappa-B-activating kinase-associated protein 1; Nak-associated protein 1; TILP |
Protein Family: | 5-azacytidine-induced protein |
UniProt Gene Name: | AZI2 |
UniProt Entry Name: | AZI2_HUMAN |