ATPAF2 Antibody (PACO22164)
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주문- SKU:
- PACO22164
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ATPAF2 Antibody (PACO22164) |
Antibody SKU: | PACO22164 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from internal of human ATPAF2. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from Jurkat cells, using ATPAF2 antibody. |
Background: | May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase). |
Synonyms: | ATP synthase mitochondrial F1 complex assembly factor 2; ATP12; ATPF2; |
UniProt Protein Function: | ATPAF2: May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase). Defects in ATPAF2 are a cause of mitochondrial complex V deficiency nuclear type 1 (MC5DN1). A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid. Belongs to the ATP12 family. |
UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: cytosol; nuclear speck Molecular Function:protein binding Disease: Mitochondrial Complex V (atp Synthase) Deficiency, Nuclear Type 1 |
NCBI Summary: | This gene encodes an assembly factor for the F(1) component of the mitochondrial ATP synthase. This protein binds specifically to the F1 alpha subunit and is thought to prevent this subunit from forming nonproductive homooligomers during enzyme assembly. This gene is located within the Smith-Magenis syndrome region on chromosome 17. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8N5M1 |
NCBI GenInfo Identifier: | 21735485 |
NCBI Gene ID: | 91647 |
NCBI Accession: | NP_663729.1 |
UniProt Secondary Accession: | Q8N5M1,Q6XYC7, A6NDE5, A8K2J2, |
UniProt Related Accession: | Q8N5M1 |
Molecular Weight: | 32.6kD |
NCBI Full Name: | ATP synthase mitochondrial F1 complex assembly factor 2 |
NCBI Synonym Full Names: | ATP synthase mitochondrial F1 complex assembly factor 2 |
NCBI Official Symbol: | ATPAF2 |
NCBI Official Synonym Symbols: | ATP12; ATP12p; LP3663; MC5DN1 |
NCBI Protein Information: | ATP synthase mitochondrial F1 complex assembly factor 2 |
UniProt Protein Name: | ATP synthase mitochondrial F1 complex assembly factor 2 |
UniProt Synonym Protein Names: | ATP12 homolog |
Protein Family: | ATP synthase |
UniProt Gene Name: | ATPAF2 |