UniProt Protein Function: | ATP6V1B2: Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the ATPase alpha/beta chains family. |
UniProt Protein Details: | Protein type:EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase Chromosomal Location of Human Ortholog: 8p21.3 Cellular Component: ruffle; microvillus; intracellular membrane-bound organelle; lysosomal membrane; integral to membrane; melanosome; plasma membrane; endomembrane system; cytosol Molecular Function:hydrogen ion transmembrane transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism; ATP binding Biological Process: ATP metabolic process; interaction with host; proton transport; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; transmembrane transport Disease: Zimmermann-laband Syndrome 2 |
NCBI Summary: | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008] |
UniProt Code: | P21281 |
NCBI GenInfo Identifier: | 12643271 |
NCBI Gene ID: | 526 |
NCBI Accession: | P21281.3 |
UniProt Related Accession: | P21281 |
Molecular Weight: | |
NCBI Full Name: | V-type proton ATPase subunit B, brain isoform |
NCBI Synonym Full Names: | ATPase H+ transporting V1 subunit B2 |
NCBI Official Symbol: | ATP6V1B2 |
NCBI Official Synonym Symbols: | DOOD; HO57; VATB; VPP3; Vma2; ZLS2; ATP6B2; ATP6B1B2 |
NCBI Protein Information: | V-type proton ATPase subunit B, brain isoform |
UniProt Protein Name: | V-type proton ATPase subunit B, brain isoform |
UniProt Synonym Protein Names: | Endomembrane proton pump 58 kDa subunit; HO57; Vacuolar proton pump subunit B 2 |
UniProt Gene Name: | ATP6V1B2 |
UniProt Entry Name: | VATB2_HUMAN |