ATP5O Antibody (PACO43722)
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주문- SKU:
- PACO43722
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ATP5O Antibody (PACO43722) |
Antibody SKU: | PACO43722 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human ATP synthase subunit O, mitochondrial protein (24-213AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: ATP5O antibody at 3µg/ml + HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 23 kDa. Observed band size: 23 kDa. | |
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO43722 at dilution of 1:100. |
Background: | Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements. |
Synonyms: | ATP synthase subunit O, mitochondrial (Oligomycin sensitivity conferral protein) (OSCP), ATP5O, ATPO |
UniProt Protein Function: | ATP5O: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Belongs to the ATPase delta chain family. |
UniProt Protein Details: | Protein type:Energy Metabolism - oxidative phosphorylation; EC 3.6.3.14; Hydrolase; Mitochondrial Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrion; nucleus; plasma membrane Molecular Function:ATPase activity; drug binding; protein binding; transmembrane transporter activity Biological Process: ATP biosynthetic process; mitochondrial ATP synthesis coupled proton transport |
NCBI Summary: | The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. [provided by RefSeq, Jul 2008] |
UniProt Code: | P48047 |
NCBI GenInfo Identifier: | 1352049 |
NCBI Gene ID: | 539 |
NCBI Accession: | P48047.1 |
UniProt Secondary Accession: | P48047,Q5U042, Q6IBI2, B2R4E2, |
UniProt Related Accession: | P48047 |
Molecular Weight: | 23,277 Da |
NCBI Full Name: | ATP synthase subunit O, mitochondrial |
NCBI Synonym Full Names: | ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit |
NCBI Official Symbol: | ATP5O |
NCBI Official Synonym Symbols: | ATPO; OSCP; HMC08D05 |
NCBI Protein Information: | ATP synthase subunit O, mitochondrial |
UniProt Protein Name: | ATP synthase subunit O, mitochondrial |
UniProt Synonym Protein Names: | Oligomycin sensitivity conferral protein; OSCP |
UniProt Gene Name: | ATP5O |
UniProt Entry Name: | ATPO_HUMAN |