ATP2C1 Antibody (PACO15839)
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주문- SKU:
- PACO15839
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ATP2C1 Antibody (PACO15839) |
Antibody SKU: | PACO15839 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human ATP2C1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15839(ATP2C1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO15839(ATP2C1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Synonyms: | ATPase, Ca++ transporting, type 2C, member 1 |
UniProt Protein Function: | ATP2C1: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD); also known as benign familial pemphigus. HHD is an autosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 6 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transporter; Hydrolase; Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel; EC 3.6.3.8 Chromosomal Location of Human Ortholog: 3q22.1 Cellular Component: Golgi membrane; Golgi apparatus; membrane; integral to membrane; trans-Golgi network Molecular Function:manganese-transporting ATPase activity; signal transducer activity; calcium-transporting ATPase activity; manganese ion binding; metal ion binding; calcium ion binding; ATP binding Biological Process: cellular calcium ion homeostasis; Golgi calcium ion homeostasis; epidermis development; positive regulation of I-kappaB kinase/NF-kappaB cascade; metabolic process; calcium ion transport; calcium-dependent cell-cell adhesion; actin cytoskeleton reorganization; manganese ion transport; cellular manganese ion homeostasis; signal transduction; Golgi calcium ion transport; transmembrane transport Disease: Benign Chronic Pemphigus |
NCBI Summary: | The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
UniProt Code: | P98194 |
NCBI GenInfo Identifier: | 68068024 |
NCBI Gene ID: | 27032 |
NCBI Accession: | P98194.3 |
UniProt Secondary Accession: | P98194,O76005, Q86V72, Q86V73, Q8N6V1, Q8NCJ7, B2RAT7 B4DSW3, B7Z3X9, G3XAH8, G8JLN9, |
UniProt Related Accession: | P98194 |
Molecular Weight: | 919 |
NCBI Full Name: | Calcium-transporting ATPase type 2C member 1 |
NCBI Synonym Full Names: | ATPase, Ca++ transporting, type 2C, member 1 |
NCBI Official Symbol: | ATP2C1 |
NCBI Official Synonym Symbols: | HHD; BCPM; PMR1; SPCA1; hSPCA1; ATP2C1A |
NCBI Protein Information: | calcium-transporting ATPase type 2C member 1; HUSSY-28; ATPase 2C1; ATPase, Ca(2+)-sequestering; ATP-dependent Ca(2+) pump PMR1; secretory pathway Ca2+/Mn2+ ATPase 1 |
UniProt Protein Name: | Calcium-transporting ATPase type 2C member 1 |
UniProt Synonym Protein Names: | ATP-dependent Ca(2+) pump PMR1 |
Protein Family: | Calcium-transporting ATPase |
UniProt Gene Name: | ATP2C1 |
UniProt Entry Name: | AT2C1_HUMAN |