ATP1B2 Antibody (PACO15837)
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주문- SKU:
- PACO15837
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ATP1B2 Antibody (PACO15837) |
Antibody SKU: | PACO15837 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human ATP1B2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15837(ATP1B2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15837(ATP1B2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases β chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). |
Synonyms: | ATPase, Na+/K+ transporting, β 2 polypeptide |
UniProt Protein Function: | ATP1B2: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. Belongs to the X(+)/potassium ATPases subunit beta family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: plasma membrane; sodium:potassium-exchanging ATPase complex Molecular Function:ATPase activator activity; ATPase binding; protein binding; sodium:potassium-exchanging ATPase activity Biological Process: cellular potassium ion homeostasis; cellular sodium ion homeostasis; leukocyte migration; positive regulation of ATPase activity; potassium ion import; protein stabilization; transport |
NCBI Summary: | The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014] |
UniProt Code: | P14415 |
NCBI GenInfo Identifier: | 125987795 |
NCBI Gene ID: | 482 |
NCBI Accession: | P14415.3 |
UniProt Secondary Accession: | P14415,O60444, A0AV17, A8K278, D3DTQ2, |
UniProt Related Accession: | P14415 |
Molecular Weight: | 33,367 Da |
NCBI Full Name: | Sodium/potassium-transporting ATPase subunit beta-2 |
NCBI Synonym Full Names: | ATPase Na+/K+ transporting subunit beta 2 |
NCBI Official Symbol: | ATP1B2 |
NCBI Official Synonym Symbols: | AMOG |
NCBI Protein Information: | sodium/potassium-transporting ATPase subunit beta-2 |
UniProt Protein Name: | Sodium/potassium-transporting ATPase subunit beta-2 |
UniProt Synonym Protein Names: | Adhesion molecule in glia; AMOG; Sodium/potassium-dependent ATPase subunit beta-2 |
Protein Family: | Sodium/potassium-transporting ATPase |
UniProt Gene Name: | ATP1B2 |
UniProt Entry Name: | AT1B2_HUMAN |