ATP1A1 Antibody (PACO21314)
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주문- SKU:
- PACO21314
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ATP1A1 Antibody (PACO21314) |
Antibody SKU: | PACO21314 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | A synthesized peptide derived from human ATPase |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of ATPase expression in PMA treated 293 whole cell lysates, The lane on the left is treated with the antigen-specific peptide. |
Background: | The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane." |
Synonyms: | A1A1, AT1A1, ATP1A1, Na+/K+ transporting, α 1 polypeptide, EC 3.6.3.9, Hypothetical protein MGC38419, Na+/K+ ATPase 1, Na,K-ATPase 1, Sodium pump 1, Sodium/potassium-transporting ATPase alpha-1 chain precursor |
UniProt Protein Function: | ATP1A1: the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na and K ions across the plasma membrane. This action creates the electrochemical gradient of Na and K, providing the energy for active transport of various nutrients. Two splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: endoplasmic reticulum; Golgi apparatus; integral to membrane; membrane; plasma membrane; protein complex; sarcolemma; sodium:potassium-exchanging ATPase complex Molecular Function:ATP binding; chaperone binding; potassium ion binding; protein binding; sodium ion binding; sodium:potassium-exchanging ATPase activity Biological Process: cellular potassium ion homeostasis; cellular sodium ion homeostasis; potassium ion import; regulation of sodium ion transport |
NCBI Summary: | The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
UniProt Code: | P05023 |
NCBI GenInfo Identifier: | 114374 |
NCBI Gene ID: | 476 |
NCBI Accession: | P05023.1 |
UniProt Secondary Accession: | P05023,Q16689, Q6LDM4, Q9UCN1, Q9UJ20, Q9UJ21, B2RBR6 B7Z2T5, B7Z3U6, F5H3A1, |
UniProt Related Accession: | P05023 |
Molecular Weight: | 113kDa |
NCBI Full Name: | Sodium/potassium-transporting ATPase subunit alpha-1 |
NCBI Synonym Full Names: | ATPase Na+/K+ transporting subunit alpha 1 |
NCBI Official Symbol: | ATP1A1 |
NCBI Protein Information: | sodium/potassium-transporting ATPase subunit alpha-1 |
UniProt Protein Name: | Sodium/potassium-transporting ATPase subunit alpha-1 |
UniProt Synonym Protein Names: | Sodium pump subunit alpha-1 |
Protein Family: | Sodium/potassium-transporting ATPase |
UniProt Gene Name: | ATP1A1 |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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